Xin Chen

Xin Chen

Department of Biology, Johns Hopkins University

Affiliated withJohns Hopkins Universitybeijing hospitalThe Johns Hopkins University

+2

Research Area

Biography

Dr. Chen received her Ph.D. in Molecular Cell & Developmental Biology from University of Texas at Austin. She was a postdoctoral fellow at Stanford University School of Medicine. Dr. Chen started her own independent research as a tenure track assistant professor at Johns Hopkins University in 2008 and is a full professor now. Dr. Chen’s laboratory investigates epigenetic regulation in various stem cell lineages during animal development, using model organisms Drosophila, C. elegans and mice.

JoVE Journal Publications

ArticleTotal : 6
Year
Chromatin Immunoprecipitation (ChIP) using <em>Drosophila</em> tissue
Publication title

Cited by 10

2012
2021
2020
2025
2025

Other Publications

Article
Year
Stem cells: what can we learn from flies?

Fly| PubMed ID: 18820440

2008
2010
2010
Epigenetic regulation of germ cell differentiation.

Current opinion in cell biology| PubMed ID: 20951019

2010
2010
Involvement of the immune system in idiosyncratic drug reactions.

Drug metabolism and pharmacokinetics| PubMed ID: 21084762

2011
2010
Preparation of low-molecular-mass peptides by enzyme autolysis oF Paphia undulata.

Preparative biochemistry & biotechnology| PubMed ID: 21108132

2010
Thermosensitive silver/polydiacetylene nanocrystals with tunable nonlinear optical properties.

Chemphyschem : a European journal of chemical physics and physical chemistry| PubMed ID: 21108275

2010
RNA interference as therapeutics for hepatocellular carcinoma.

Recent patents on anti-cancer drug discovery| PubMed ID: 21110827

2011
2010
[Clinical application of extracorporeal membrane oxygenation for severe heart failure during peri-operative period of end-stage cardiopathy].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue| PubMed ID: 21122208

2010
2010
2011
2011
2011
2011
2011
2010
[Progress on the study of estimating influenza-associated deaths under regression models.]

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi| PubMed ID: 21163110

2010
2011
2011
2010
2011
2010
2010
2010
2010
2011
2011
2010
[Estimation and prediction of the epidemic situation of acquired immunodeficiency syndrome in Jiangsu province].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]| PubMed ID: 21215130

2010
2010
2010
Observed network dynamics from altering the balance between excitatory and inhibitory neurons in cultured networks.

Physical review. E, Statistical, nonlinear, and soft matter physics| PubMed ID: 21230108

2010
2011
Three new flavonoid glycosides from Pinus tabulaeformis Carr.

Journal of Asian natural products research| PubMed ID: 21253948

2011
2011
2011
2011
Calcifying epithelial odontogenic tumour showing malignant transformation: a case report and review of the literature.

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)| PubMed ID: 21264368

2010
2011
2011
2011
Small interfering RNA targeting IKKβ prevents renal ischemia-reperfusion injury in rats.

American journal of physiology. Renal physiology| PubMed ID: 21289055

2011
2011
2011
2011
2011
[Preliminary research on the relationship between inhibitory effect of triamcinolone acetonide on hypertrophic scar and oxygen free radicals in rabbits].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery| PubMed ID: 21322265

2010
Crystallization of Calcium Carbonate on Chitosan Substrates in the Presence of Regenerated Silk Fibroin.

Langmuir : the ACS journal of surfaces and colloids| PubMed ID: 21323338

2011
Soft robotics for chemists.

Angewandte Chemie (International ed. in English)| PubMed ID: 21328664

2011
2011
Anomalous left superior pulmonary venous connection with intact interatrial septum.

Echocardiography (Mount Kisco, N.Y.)| PubMed ID: 21349105

2011
2010
Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

Bioorganic & medicinal chemistry letters| PubMed ID: 21353551

2011
2011
[Influence of arbuscular mycorrhizal inoculation on growth and phoxim residue of carrot (Daucus carota L.)].

Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.]| PubMed ID: 21360902

2010
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
[Analysis of frequency-domain and window effect for cellular inner and outer membranes subjected to pulsatile electric field].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi| PubMed ID: 21485174

2011
2011
[Polymorphism at codons 136, 141 and 154 in the ovine prion protein gene in the state of Xinjiang].

Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji| PubMed ID: 21513168

2010
2011
2011
A novel technique of semi-aerobic aged refuse biofilter for leachate treatment.

Waste management (New York, N.Y.)| PubMed ID: 21514812

2011
2011
2011
2011
Innovative drug R&D in China.

Nature reviews. Drug discovery| PubMed ID: 21532556

2011
2011
2011
Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.

American journal of physiology. Heart and circulatory physiology| PubMed ID: 21572007

2011
2011
2011
[Clinical features of women with idiopathic premature ovarian failure].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University| PubMed ID: 21602150

2011
2011
2011
2011
Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins.

American journal of physiology. Gastrointestinal and liver physiology| PubMed ID: 21617116

2011
2011
[The effects of Berberine on growth of Immorto-Min colonic epithelial cell line].

Zhonghua nei ke za zhi [Chinese journal of internal medicine]| PubMed ID: 21624228

2011
[A correlative study on Bisphenol A and recurrent spontaneous abortion].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]| PubMed ID: 21624331

2011
2011
Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21628561

2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
Aortic valve tear with severe aortic regurgitation following blunt chest trauma.

Journal of cardiothoracic surgery| PubMed ID: 21682925

2011
2011
2011
2011
2011
Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases| PubMed ID: 21742059

2011
2011
2011
2011
[Clinical observation of acupuncture and massage therapy for temporomandibular joint disorders].

Shanghai kou qiang yi xue = Shanghai journal of stomatology| PubMed ID: 21779740

2011
2011
2011
Biochemical characterization of a calcium-sensitive protein kinase LeCPK2 from tomato.

Indian journal of biochemistry & biophysics| PubMed ID: 21793304

2011
2011
2011
[Investigation and protection for endangered Coptis deltoidea].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica| PubMed ID: 21809564

2011
2011
2012
2012
2011
2011
Poly[(μ(5)-2,6-dimethyl-pyridine-3,5-dicarboxyl-ato)zinc].

Acta crystallographica. Section E, Structure reports online| PubMed ID: 21836951

2011
Exploiting the Functional and Taxonomic Structure of Genomic Data by Probabilistic Topic Modeling.

IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM| PubMed ID: 21844637

2011
2011
2011
Self-assembly of a peptide amphiphile based on hydrolysed Bombyx mori silk fibroin.

Chemical communications (Cambridge, England)| PubMed ID: 21858302

2011
2011
2011
Thermal insight of mechanically activated bile acid powders.

International journal of pharmaceutics| PubMed ID: 21872650

2011
[Effect of ciglitazone on THP-1 macrophage CD36 expression and cholesterol influx].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology| PubMed ID: 21882481

2011
2011
Polydiacetylene vesicles containing αα-cyclodextrin and azobenzene as photocontrolled nanocarriers.

Chemphyschem : a European journal of chemical physics and physical chemistry| PubMed ID: 21898752

2011
[Two single nucleotide polymorphisms on chromosome 3 and the risk of prostate cancer in Chinese men].

Zhonghua nan ke xue = National journal of andrology| PubMed ID: 21898988

2011
Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers.

Laboratory investigation; a journal of technical methods and pathology| PubMed ID: 21912379

2012
2011
Applied anatomy for pituitary adenoma resection.

Chinese medical journal| PubMed ID: 21933555

2011
2011
2011
Methyl groups of trimethylamine N-oxide orient away from hydrophobic interfaces.

Journal of the American Chemical Society| PubMed ID: 21967088

2011
2012
2011
2012
Inferring 3D kinematics of carpal bones from single view fluoroscopic sequences.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention| PubMed ID: 21995088

2011
2011
2011
2012
Paclitaxel-loaded silk fibroin nanospheres.

Journal of biomedical materials research. Part A| PubMed ID: 22021221

2012
2011
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 22025698

2011
Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination.

The Journal of biological chemistry| PubMed ID: 22027892

2011
2011
2012
2012
2011
2011
Ecological mechanisms underlying the sustainability of the agricultural heritage rice-fish coculture system.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 22084110

2011
2012
2011
2012
Multigait soft robot.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 22123978

2011
A citric acid-derived ligand for modular functionalization of metal oxide surfaces via "click" chemistry.

Langmuir : the ACS journal of surfaces and colloids| PubMed ID: 22145802

2012
2011
Results of molecular docking as descriptors to predict human serum albumin binding affinity.

Journal of molecular graphics & modelling| PubMed ID: 22153983

2012
2010
2012
[A cost-benefit analysis of the influenza H1N1 vaccination in the primary and junior school in Shanghai].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]| PubMed ID: 22169697

2011
2011
2012
2012
2012
2011
(Z)-1-[2-(Trifluoro-meth-yl)benzyl-idene]thio-semicarbazide.

Acta crystallographica. Section E, Structure reports online| PubMed ID: 22199862

2011
2012
2011
2012
2012
2012
2012
2012
Effect of ZnO Nanoparticle Properties on Dye-Sensitized Solar Cell Performance.

ACS applied materials & interfaces| PubMed ID: 22321170

2012
2012
2012
2012
[Construction of tissue engineering bone with bone marrow stromal cell sheets].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology| PubMed ID: 22333357

2011
2011
2012
2011
[Advances in research on haematopoietic stem cell transplantation-associated thrombotic microangiopathy].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi| PubMed ID: 22338184

2011
[Progress in rearch on allogeneic hematopoietic stem cell transplantation for chronic lymphocytic leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi| PubMed ID: 22338186

2011
2012
2012
2012
2012
Prevalence and characteristics of anemia in patients with solid cancers at diagnosis in southwest china.

Asian Pacific journal of cancer prevention : APJCP| PubMed ID: 22393948

2011
Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism.

Journal of molecular neuroscience : MN| PubMed ID: 22399228

2012
2012
2012
2012
2012
2012
[Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men].

Zhonghua nan ke xue = National journal of andrology| PubMed ID: 22741436

2012
2012
2012
2012
2012
2012
2013
Alternative splicing switching in stem cell lineages.

Frontiers in biology| PubMed ID: 23399987

2013
Association of six susceptibility Loci with prostate cancer in northern chinese men.

Asian Pacific journal of cancer prevention : APJCP| PubMed ID: 23464444

2012
Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology| PubMed ID: 23681658

2013
Susceptibility Loci associations with prostate cancer risk in northern chinese men.

Asian Pacific journal of cancer prevention : APJCP| PubMed ID: 23803082

2013
[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients].

Zhonghua zhong liu za zhi [Chinese journal of oncology]| PubMed ID: 23985253

2013
Epigenetic regulation in adult stem cells and cancers.

Cell & bioscience| PubMed ID: 24172544

2013
2014
2014
Epigenetic regulation of germ cells-remember or forget?

Current opinion in genetics & development| PubMed ID: 25930104

2015
2015
2015
2015
The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men.

International journal of environmental research and public health| PubMed ID: 26828504

2016
2016
2017
2017
2017
The Inherent Asymmetry of DNA Replication.

Annual review of cell and developmental biology| PubMed ID: 28800257

2017
2017
2018
2015
Symmetry from Asymmetry or Asymmetry from Symmetry?

Cold Spring Harbor symposia on quantitative biology| PubMed ID: 29348326

2017
2018
Protecting and Diversifying the Germline.

Genetics| PubMed ID: 29378808

2018
2018
Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 30084835

2019
Comparison of Eversion Carotid Endarterectomy and Patch Carotid Endarterectomy: A Retrospective Study of 6 Years of Experience.

Medical science monitor : international medical journal of experimental and clinical research| PubMed ID: 30127336

2018
2018
2018
2019
2020
2019
Regulation of Drosophila germline stem cells.

Current opinion in cell biology| PubMed ID: 31014993

2019
2019
2019
2019
2019
2019
2020
2020
Single-cyst transcriptome analysis of male germline stem cell lineage.

Development (Cambridge, England)| PubMed ID: 32122991

2020
2020
2020
2020
2020
2023
Transcription factors in ferroptotic cell death.

Cancer gene therapy| PubMed ID: 32123318

2020
2020
Ferroptosis: machinery and regulation.

Autophagy| PubMed ID: 32804006

2021
Iron Metabolism in Ferroptosis.

Frontiers in cell and developmental biology| PubMed ID: 33117818

2020
2021
2021
2021
Cellular degradation systems in ferroptosis.

Cell death and differentiation| PubMed ID: 33462411

2021
Broadening horizons: the role of ferroptosis in cancer.

Nature reviews. Clinical oncology| PubMed ID: 33514910

2021
Characteristics and Biomarkers of Ferroptosis.

Frontiers in cell and developmental biology| PubMed ID: 33553189

2021
2021
Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg?

Frontiers in cell and developmental biology| PubMed ID: 33842471

2021
Targeting Ubiquitin-Proteasome System With Copper Complexes for Cancer Therapy.

Frontiers in molecular biosciences| PubMed ID: 33928122

2021
2021
Cell death in pancreatic cancer: from pathogenesis to therapy.

Nature reviews. Gastroenterology & hepatology| PubMed ID: 34331036

2021
Organelle-specific regulation of ferroptosis.

Cell death and differentiation| PubMed ID: 34465893

2021
2021
The role of ferroptosis in lung cancer.

Biomarker research| PubMed ID: 34742351

2021
2022
2022
2023
2022
2022
2022
2022
2023
2023
2023
2023
2023
2023
2024
2024
2024
2024
2024