microrna-detection-prostate-tumors-quantitative-real-time-pcr

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

MicroRNAs (miRNAs) are single-stranded, 18&#x2013;24 nucleotide long, non-coding RNA molecules. They are involved in virtually every cellular process ...

reconstruction-3-dimensional-histology-volume-its-application-to

Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands

Histology volume reconstruction facilitates the study of 3D shape and volume change of an organ at the level of macrostructures made up of cells. It can ...

University of Toronto

Sunnybrook Research Institute

The distinction between renal oncocytoma and renal cell carcinoma, especially chromophobe renal cell carcinoma and clear cell carcinoma with oncocytic features, is important due to the different biologic potentials of these tumors. RING E3 ligases have the subject of intense studies for their roles in many diseases including cancer and as potential therapeutic targets. All RING E3 ligases, including BCA2, contain a consensus protein sequence that would complex two or more zinc ions in the expressed protein. Identification of which ubiquitin ligases specifically affect distinct cellular processes is essential to the development of targeted therapeutics in these tumors. The ubiquitin-proteasome system regulates the turnover of proteins that have essential roles in the cell cycle, apoptosis, DNA damage repair, and in protein trafficking, which makes this pathway a target for oncogenic events. In this study, we investigated expression of BCA2 in renal oncocytoma and renal cell carcinoma. A total of 158 patients were included in the study. Our study has shown that 114/114 (100 %) cases of renal cell carcinoma were negative for BCA2. All 38 (100 %) cases of renal oncocytoma were positive for BCA2, and 6/6 (100 %) cases designated as oncocytic neoplasm which favor oncocytoma were also positive for BCA2. This is the first study to date evaluating the expression of BCA2 in renal oncocytoma. BCA2 could serve as a marker that may be utilized in the distinction between renal oncocytoma and its mimickers.

BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms.

Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted peptides that play major roles in regulating the normal development and maturation of mammary gland. While Igfbp7 has been shown to decrease breast tumor growth, its role in regulating the normal mammary gland development has not been studied. To this end, we generated Igfbp7-null mice and examined the development and maturation of mammary glands in the virgin, pregnant and lactating animals.

ArticleTotal : 2	Year
Publication title Cited by 18	2012
Publication title Cited by 10	2014

Article	Year
The open cancer journal\| PubMed ID: 21179390	2010
BMC cancer\| PubMed ID: 22315970	2012
BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 23242606	2013
Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland. PloS one\| PubMed ID: 24505323	2014

Stephanie Bacopulos

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