Baljit S. Khakh

Departments of Physiology and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles

Affiliated withDavid Geffen School of Medicine, University of California, Los Angeles University of California Los Angeles

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 16	2009
Publication title Cited by 13	2009
Publication title Cited by 24	2014
Publication title Cited by 19	2018
Publication title Cited by 23	2019

Other Publications

Article	Year
Control of P2X(2) channel permeability by the cytosolic domain. The Journal of general physiology\| PubMed ID: 12149275	2002
ATP modulation of excitatory synapses onto interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12917379	2003
ATP-gated P2X channels. Current biology : CB\| PubMed ID: 14711422	2004
Contribution of calcium ions to P2X channel responses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15056721	2004
ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15456834	2004
Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15548662	2004
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics. The Journal of biological chemistry\| PubMed ID: 15556949	2005
An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection flu... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16033901	2005
P2X receptors as cell-surface ATP sensors in health and disease. Nature\| PubMed ID: 16885977	2006
Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360502	2007
Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes. The Journal of general physiology\| PubMed ID: 17504911	2007
Tracking transmitter-gated P2X cation channel activation in vitro and in vivo. Nature methods\| PubMed ID: 18084300	2008
Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18579739	2008
ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release. Neuropharmacology\| PubMed ID: 18601937	2009
Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. The Journal of biological chemistry\| PubMed ID: 18635539	2008
ATP-gated P2X cation-channels. Neuropharmacology\| PubMed ID: 18657557	2009
Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18689682	2008
Tunable calcium current through TRPV1 receptor channels. The Journal of biological chemistry\| PubMed ID: 18775990	2008
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Science signaling\| PubMed ID: 18922787	2008
The double life of ATP. Scientific American\| PubMed ID: 20058644	2009
Gated access to the pore of a P2X receptor: structural implications for closed-open transitions. The Journal of biological chemistry\| PubMed ID: 20093367	2010
P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. The Journal of general physiology\| PubMed ID: 20231374	2010
A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nature neuroscience\| PubMed ID: 20495558	2010
Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters. Neuron glia biology\| PubMed ID: 21205365	2010
Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21697385	2011
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21808018	2011
Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22090499	2011
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature neuroscience\| PubMed ID: 22158513	2012
Allosteric modulation of Ca2+ flux in a ligand-gated cation channel (P2X4) by actions on lateral portals. The Journal of biological chemistry\| PubMed ID: 22219189	2012
Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK. The Journal of biological chemistry\| PubMed ID: 22393055	2012
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23035093	2012
Neuromodulation by extracellular ATP and P2X receptors in the CNS. Neuron\| PubMed ID: 23040806	2012
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23077035	2012
Genetically encoded calcium indicators and astrocyte calcium microdomains. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 23264008	2013
Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. The Journal of general physiology\| PubMed ID: 23589582	2013
ATP-gated ion channels mediate adaptation to elevated sound levels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23592720	2013
TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23761909	2013
Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. Biomaterials\| PubMed ID: 24314556	2014
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nature neuroscience\| PubMed ID: 24686787	2014
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. The Journal of biological chemistry\| PubMed ID: 24706758	2014
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron\| PubMed ID: 24742463	2014
Astrocytes and Huntington's disease. ACS chemical neuroscience\| PubMed ID: 24842291	2014
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. The Journal of general physiology\| PubMed ID: 24935743	2014
Slow neuromodulation mediated by ATP P2X receptors. Neuron\| PubMed ID: 25033174	2014
ATP-gated P2X receptors in health and disease. Frontiers in cellular neuroscience\| PubMed ID: 25104924	2014
Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo. Nature neuroscience\| PubMed ID: 25894291	2015
Diversity of astrocyte functions and phenotypes in neural circuits. Nature neuroscience\| PubMed ID: 26108722	2015
Probing the Complexities of Astrocyte Calcium Signaling. Trends in cell biology\| PubMed ID: 26896246	2016
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27013675	2016
Astrocyte scar formation aids central nervous system axon regeneration. Nature\| PubMed ID: 27027288	2016
P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27559172	2016
New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron\| PubMed ID: 27939582	2016
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends in neurosciences\| PubMed ID: 28578789	2017
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron\| PubMed ID: 28712653	2017
An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales. Neuron\| PubMed ID: 29621490	2018
Active role of capillary pericytes during stimulation-induced activity and spreading depolarization. Brain : a journal of neurology\| PubMed ID: 30053174	2018
Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron\| PubMed ID: 30174118	2018
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. Nature communications\| PubMed ID: 30755613	2019
Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell\| PubMed ID: 31031006	2019
Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell reports\| PubMed ID: 31116972	2019
The Emerging Nature of Astrocyte Diversity. Annual review of neuroscience\| PubMed ID: 31283899	2019
Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function. Trends in neurosciences\| PubMed ID: 31351745	2019