Howard L. Weiner

Center for Neurologic Diseases, Harvard Medical School

Affiliated withHarvard Medical School Brigham and Women's Hospital, Harvard Medical School Brigham and Women's Hospital and Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 37	2012
Publication title	2020
Publication title Cited by 7	2019

Other Publications

Article	Year
Oral tolerance, an active immunologic process mediated by multiple mechanisms. The Journal of clinical investigation\| PubMed ID: 11032852	2000
CNS drugs\| PubMed ID: 11772115	2002
International immunology\| PubMed ID: 11809732	2002
Journal of magnetic resonance imaging : JMRI\| PubMed ID: 11836778	2002
Neurosurgery\| PubMed ID: 11904022	2002
European journal of immunology\| PubMed ID: 11920578	2002
Journal of neuroimmunology\| PubMed ID: 11960649	2002
Plastic and reconstructive surgery\| PubMed ID: 11994607	2002
Journal of neuroimmunology\| PubMed ID: 12020972	2002
Clinical immunology (Orlando, Fla.)\| PubMed ID: 12027417	2002
Nature medicine\| PubMed ID: 16715091	2006
Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12193686	2002
Circulation\| PubMed ID: 12270867	2002
Cancer research\| PubMed ID: 12438220	2002
The American journal of pathology\| PubMed ID: 12466141	2002
Nature\| PubMed ID: 12490962	2002
Journal of child neurology\| PubMed ID: 12503646	2002
Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594253	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594277	2003
Neurology\| PubMed ID: 12601106	2003
Journal of autoimmunity\| PubMed ID: 12657527	2003
FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12724345	2003
Markers of cellular proliferation are expressed in cortical tubers. Annals of neurology\| PubMed ID: 12731003	2003
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. The Journal of experimental medicine\| PubMed ID: 12732654	2003
Journal of pediatric hematology/oncology\| PubMed ID: 12759623	2003
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of clinical investigation\| PubMed ID: 12897209	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12928365	2003
Journal of autoimmunity\| PubMed ID: 12935782	2003
Science (New York, N.Y.)\| PubMed ID: 14593170	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14662856	2003
IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14688366	2004
Journal of neuroimmunology\| PubMed ID: 14698862	2004
Immunologic research\| PubMed ID: 14713719	2003
International immunology\| PubMed ID: 14734610	2004
Pediatric clinics of North America\| PubMed ID: 15062675	2004
The Journal of experimental medicine\| PubMed ID: 15067033	2004
Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 15228759	2004
Journal of the neurological sciences\| PubMed ID: 15261554	2004
Epilepsia\| PubMed ID: 15281957	2004
Archives of neurology\| PubMed ID: 15477521	2004
Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. Journal of autoimmunity\| PubMed ID: 15501390	2004
Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 15505369	2004
Journal of child neurology\| PubMed ID: 15563015	2004
Cellular immunology\| PubMed ID: 15598424	2004
Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15611503	2004
Neurologic clinics\| PubMed ID: 15661097	2005
Neurosurgery\| PubMed ID: 15670380	2005
Annals of the New York Academy of Sciences\| PubMed ID: 15681760	2004
Archives of neurology\| PubMed ID: 15883268	2005
Journal of neuroimmunology\| PubMed ID: 15885317	2005
Journal of the neurological sciences\| PubMed ID: 15894335	2005
Journal of neurosurgery\| PubMed ID: 16028775	2005
Immunological reviews\| PubMed ID: 16048553	2005
The Journal of clinical investigation\| PubMed ID: 16100572	2005
The ICOS molecule plays a crucial role in the development of mucosal tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16301640	2005
Epileptic disorders : international epilepsy journal with videotape\| PubMed ID: 16338674	2005
Neurosurgical focus\| PubMed ID: 16398472	2005
Journal of autoimmunity\| PubMed ID: 16426816	2006
Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta. Journal of autoimmunity\| PubMed ID: 16439314	2006
Neurosurgical focus\| PubMed ID: 16459994	2006
Journal of neuroimmunology\| PubMed ID: 16533538	2006
International immunology\| PubMed ID: 16540527	2006
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16549802	2006
Annals of neurology\| PubMed ID: 16634007	2006
Nature reviews. Immunology\| PubMed ID: 16639431	2006
Nature\| PubMed ID: 16648838	2006
Pediatrics\| PubMed ID: 16651302	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16751425	2006
Journal of neuroimmunology\| PubMed ID: 16806500	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16887994	2006
Inflammation & allergy drug targets\| PubMed ID: 16918481	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16951385	2006
A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmunity reviews\| PubMed ID: 17027888	2006
Clinical & developmental immunology\| PubMed ID: 17162357	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182552	2007
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182553	2007
Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17371954	2007
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 17434098	2007
Diabetes\| PubMed ID: 17456848	2007
Epilepsia\| PubMed ID: 17484758	2007
Journal of the neurological sciences\| PubMed ID: 17521671	2007
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 17599713	2007
Epilepsy & behavior : E&B\| PubMed ID: 17613275	2007
What does the future hold for cell-based tolerogenic therapy? Nature reviews. Immunology\| PubMed ID: 17653127	2007
Neurosurgery\| PubMed ID: 17762730	2007
Nature immunology\| PubMed ID: 17994022	2007
Journal of autoimmunity\| PubMed ID: 18191540	2008
Epilepsia\| PubMed ID: 18226172	2008
Nature biotechnology\| PubMed ID: 18259174	2008
Journal of neurology\| PubMed ID: 18317671	2008
The Journal of clinical investigation\| PubMed ID: 18340379	2008
Annals of neurology\| PubMed ID: 18360829	2008
Nature\| PubMed ID: 18362915	2008
Journal of neuroimmunology\| PubMed ID: 18378324	2008
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal of neuroimmunology\| PubMed ID: 18403025	2008
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18490732	2008
Journal of cellular and molecular medicine\| PubMed ID: 18505469	2008
Brain : a journal of neurology\| PubMed ID: 18567923	2008
Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex. Acta neuropathologica\| PubMed ID: 18581125	2008
Neurosurgery\| PubMed ID: 18596454	2008
Lancet neurology\| PubMed ID: 18635014	2008
Neurosurgical focus\| PubMed ID: 18759614	2008
Journal of the neurological sciences\| PubMed ID: 18804221	2008
Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helpe... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941193	2008
Nature reviews. Drug discovery\| PubMed ID: 18974749	2008
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Archives of neurology\| PubMed ID: 19001162	2008
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19017937	2008
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19028871	2008
Journal of the American Statistical Association\| PubMed ID: 19081806	2007
Journal of autoimmunity\| PubMed ID: 19181483	2009
Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 19192042	2009
Rate of brain atrophy in benign vs early multiple sclerosis. Archives of neurology\| PubMed ID: 19204160	2009
The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19237575	2009
NeuroImage\| PubMed ID: 19281850	2009
European journal of immunology\| PubMed ID: 19283716	2009
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Annals of neurology\| PubMed ID: 19334069	2009
Pediatric neurosurgery\| PubMed ID: 19440004	2009
International immunology\| PubMed ID: 19515797	2009
Nature genetics\| PubMed ID: 19525953	2009
Journal of neurosurgery. Pediatrics\| PubMed ID: 19569916	2009
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19625647	2009
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19675171	2009
Nature immunology\| PubMed ID: 19684606	2009
Journal of clinical immunology\| PubMed ID: 19756989	2010
Epilepsy & behavior : E&B\| PubMed ID: 19767244	2009
European journal of immunology\| PubMed ID: 19768696	2009
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 19888926	2011
Journal of neuroimmunology\| PubMed ID: 19931190	2010
The association between cognitive impairment and quality of life in patients with early multiple sclerosis. Journal of the neurological sciences\| PubMed ID: 19944429	2010
PloS one\| PubMed ID: 20221429	2010
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20368276	2010
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20368430	2010
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20445103	2010
Epilepsia\| PubMed ID: 20491878	2010
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534530	2010
Journal of neuroimmunology\| PubMed ID: 20580440	2010
Journal of neurosurgery. Pediatrics\| PubMed ID: 20672932	2010
Nature immunology\| PubMed ID: 20676092	2010
Nature immunology\| PubMed ID: 20676095	2010
Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20720210	2010
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20720212	2010
Journal of immunological methods\| PubMed ID: 20837018	2010
Archives of neurology\| PubMed ID: 20837847	2010
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery\| PubMed ID: 20853002	2011
Ocular immunology and inflammation\| PubMed ID: 20887202	2010
Annals of neurology\| PubMed ID: 21061396	2010
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21068375	2010
Neurosurgery\| PubMed ID: 21099705	2011
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal of neuroimmunology\| PubMed ID: 21115201	2011
PloS one\| PubMed ID: 21124798	2010
Nature medicine\| PubMed ID: 21131957	2011
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PloS one\| PubMed ID: 21152065	2010
Epilepsy & behavior : E&B\| PubMed ID: 21288778	2011
Neurobiology of aging\| PubMed ID: 21371785	2012
Patient reported outcomes in benign multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 21372114	2011
Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 21429902	2011
The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 21447022	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 21456917	2011
Oral tolerance. Immunological reviews\| PubMed ID: 21488901	2011
PloS one\| PubMed ID: 21494571	2011
Journal of neurosurgery. Pediatrics\| PubMed ID: 21631205	2011
Epilepsia\| PubMed ID: 21671922	2011
Immunobiology\| PubMed ID: 21676485	2011
Cognitive deterioration in patients with early multiple sclerosis: a 5-year study. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 21746743	2012
Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 21777829	2011
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21788439	2011
In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PloS one\| PubMed ID: 21886804	2011
Gut-tropic T cells that express integrin Î±4Î²7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology\| PubMed ID: 21925467	2011
European journal of immunology\| PubMed ID: 22002875	2012
PloS one\| PubMed ID: 22039443	2011
Induction of immunological tolerance by oral anti-CD3. Clinical & developmental immunology\| PubMed ID: 22162715	2012
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. Journal of the neurological sciences\| PubMed ID: 22209496	2012
Epilepsy control following intracranial monitoring without resection in young children. Epilepsia\| PubMed ID: 22242686	2012
IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner. Immunology and cell biology\| PubMed ID: 22430249	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 22462706	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 22462708	2012
Journal of neuroimmunology\| PubMed ID: 22579051	2012
Glia\| PubMed ID: 22653784	2012
Immunological reviews\| PubMed ID: 22725961	2012
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22745170	2012
PloS one\| PubMed ID: 22768094	2012
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity\| PubMed ID: 23123061	2012
IFN-γ limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23125412	2012
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology\| PubMed ID: 24174586	2013
Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE. Experimental neurology\| PubMed ID: 24552689	2014
In vivo anti-LAP mAb enhances IL-17/IFN-γ responses and abrogates anti-CD3-induced oral tolerance. International immunology\| PubMed ID: 25194146	2015
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. The Journal of clinical investigation\| PubMed ID: 25642768	2015
MicroRNA-21, T helper lineage and autoimmunity. Oncotarget\| PubMed ID: 25991670	2015
Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. Journal of neuroinflammation\| PubMed ID: 26714756	2015
The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell host & microbe\| PubMed ID: 26764595	2016
Immunology. How does the immune system tolerate food? Science (New York, N.Y.)\| PubMed ID: 26912876	2016
Power estimation for non-standardized multisite studies. NeuroImage\| PubMed ID: 27039700	2016
Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. Journal of autoimmunity\| PubMed ID: 27157273	2016
IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain : a journal of neurology\| PubMed ID: 27246324	2016
Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. Journal of autoimmunity\| PubMed ID: 27745778	2017
Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 27915033	2017
IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28039301	2017
Targeting latency-associated peptide promotes antitumor immunity. Science immunology\| PubMed ID: 28763794	2017
History and mechanisms of oral tolerance. Seminars in immunology\| PubMed ID: 28774470	2017
A two-year study using cerebral gray matter volume to assess the response to fingolimod therapy in multiple sclerosis. Journal of the neurological sciences\| PubMed ID: 29146095	2017
Transcriptional signature of human pro-inflammatory T17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nature communications\| PubMed ID: 29150604	2017
Microbiota Signaling Pathways that Influence Neurologic Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 29340928	2018
Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron\| PubMed ID: 29470968	2018
Microglial signatures and their role in health and disease. Nature reviews. Neuroscience\| PubMed ID: 30206328	2018
Acute microglia ablation induces neurodegeneration in the somatosensory system. Nature communications\| PubMed ID: 30385785	2018
The sex-specific interaction of the microbiome in neurodegenerative diseases. Brain research\| PubMed ID: 31419428	2019
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell reports\| PubMed ID: 31553906	2019
Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila. Cell host & microbe\| PubMed ID: 31784260	2019
A One-Two Punch in the Gut May Trigger Multiple Sclerosis. Immunity\| PubMed ID: 33053328	2020