Darrell N. Kotton

Center for Regenerative Medicine (CReM), Boston University School of Medicine

Affiliated withBoston University School of Medicine Boston University and Boston Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 80	2012
Publication title Cited by 8	2022

Other Publications

Article	Year
Stem cell antigen-1 expression in the pulmonary vascular endothelium. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12611818	2003
Side population cells and Bcrp1 expression in lung. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12626330	2003
Translational physiology: origin and phenotype of lung side population cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15047566	2004
Lung stem cells: new paradigms. Experimental hematology\| PubMed ID: 15050743	2004
Embryonic lung side population cells are hematopoietic and vascular precursors. American journal of respiratory cell and molecular biology\| PubMed ID: 15802552	2005
A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity. Blood\| PubMed ID: 15870171	2005
Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15922964	2005
Failure of bone marrow to reconstitute lung epithelium. American journal of respiratory cell and molecular biology\| PubMed ID: 15961722	2005
Exogenous control of mammalian gene expression via modulation of translational termination. Nature medicine\| PubMed ID: 16892063	2006
Lung stem cells. Cell and tissue research\| PubMed ID: 17805578	2008
Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages. Journal of immunological methods\| PubMed ID: 17967462	2008
The prolonged life-span of alveolar macrophages. American journal of respiratory cell and molecular biology\| PubMed ID: 18192503	2008
Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 18200564	2008
Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. American journal of respiratory cell and molecular biology\| PubMed ID: 18323534	2008
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem cells (Dayton, Ohio)\| PubMed ID: 19096035	2009
Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PloS one\| PubMed ID: 19415118	2009
Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction. Chest\| PubMed ID: 19666756	2009
Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem cells (Dayton, Ohio)\| PubMed ID: 19904830	2010
Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. The Journal of clinical investigation\| PubMed ID: 20038801	2010
The role of skin-derived dendritic cells in CD8+ T cell priming following immunization with lentivectors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20357252	2010
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem cells (Dayton, Ohio)\| PubMed ID: 20715179	2010
FOXO1 modulates osteoblast differentiation. Bone\| PubMed ID: 21281751	2011
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of clinical investigation\| PubMed ID: 21537085	2011
Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proceedings of the American Thoracic Society\| PubMed ID: 21653526	2011
A shift from cell cultures to creatures: in vivo imaging of small animals in experimental regenerative medicine. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21952170	2011
Programmatic change: lung disease research in the era of induced pluripotency. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21984571	2011
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. The Journal of physiology\| PubMed ID: 22025662	2011
Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration. Biochemical and biophysical research communications\| PubMed ID: 22142851	2012
Are embryonic stem and induced pluripotent stem cells the same or different? Implications for their potential therapeutic use. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22186787	2012
Case records of the Massachusetts General Hospital. Case 2-2012. A 63-year-old woman with dyspnea and rapidly progressive respiratory failure. The New England journal of medicine\| PubMed ID: 22256809	2012
Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells. American journal of respiratory cell and molecular biology\| PubMed ID: 22323363	2012
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell stem cell\| PubMed ID: 22482503	2012
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell stem cell\| PubMed ID: 22482505	2012
Next-generation regeneration: the hope and hype of lung stem cell research. American journal of respiratory and critical care medicine\| PubMed ID: 22517787	2012
Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation\| PubMed ID: 22914687	2012
The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation. The Journal of biological chemistry\| PubMed ID: 22955271	2012
The 2012 Nobel Prize in physiology or medicine: democratizing pluripotency for lung researchers. American journal of respiratory and critical care medicine\| PubMed ID: 23204376	2012
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. The Journal of general physiology\| PubMed ID: 23277474	2013
Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23403494	2013
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood\| PubMed ID: 23723449	2013
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell stem cell\| PubMed ID: 23746980	2013
Lung regeneration: mechanisms, applications and emerging stem cell populations. Nature medicine\| PubMed ID: 25100528	2014
Derivation of Endodermal Progenitors From Pluripotent Stem Cells. Journal of cellular physiology\| PubMed ID: 25160562	2015
Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem cell reports\| PubMed ID: 25772471	2015
Embryonic and induced pluripotent stem cells for lung regeneration. Annals of the American Thoracic Society\| PubMed ID: 25830836	2015
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem cell reports\| PubMed ID: 25843048	2015
Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 26593959	2015
Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors. Bio-protocol\| PubMed ID: 27453901	2012
Regenerative therapy for hypothyroidism: Mechanisms and possibilities. Molecular and cellular endocrinology\| PubMed ID: 27876515	2017
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell stem cell\| PubMed ID: 28366587	2017
Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 28463226	2017
Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials\| PubMed ID: 28942128	2017
Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development (Cambridge, England)\| PubMed ID: 28947536	2017
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell stem cell\| PubMed ID: 28965766	2017
Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. The Journal of clinical investigation\| PubMed ID: 29400691	2018
Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem cell reports\| PubMed ID: 29657097	2018
Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30796179	2019
Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering. Stem cell reports\| PubMed ID: 31422908	2019
Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nature protocols\| PubMed ID: 31732721	2019
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell stem cell\| PubMed ID: 32004478	2020
The in vivo genetic program of murine primordial lung epithelial progenitors. Nature communications\| PubMed ID: 32005814	2020
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell stem cell\| PubMed ID: 32891189	2020
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell stem cell\| PubMed ID: 32979316	2020
Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annual review of physiology\| PubMed ID: 33074772	2021
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 33098807	2021
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular cell\| PubMed ID: 33259812	2020
Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Frontiers in endocrinology\| PubMed ID: 33959101	2021
Differentiation of human pluripotent stem cells into functional airway basal stem cells. STAR protocols\| PubMed ID: 34355203	2021
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34413211	2021
Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell reports\| PubMed ID: 34469722	2021
Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration. Frontiers in endocrinology\| PubMed ID: 35211095	2022
Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature\| PubMed ID: 35355013	2022