measurement-of-compressive-stress-strain-response-at-small-strains

Measurement of Compressive Stress-Strain Response at Small-Strains

This study developed a measurement method capable of precisely evaluating the mechanical behavior of materials and microdevices in the small-strain ...

fabrication-master-mold-for-microneedles-with-micron-sized-air-vent

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Microneedles (MNs) are a novel drug-delivery system that can penetrate the skin barrier in a minimally invasive way to deliver drugs. Because they are ...

inje university

Treatment outcomes between FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and GNP (gemcitabine with albumin-bound paclitaxel) as first-line chemotherapy regimens for metastatic pancreatic cancer (PC) were assessed according to ethnic groups categorized as Western or Asian subgroups. PubMed, EMBASE, and Cochrane library were searched. Thirteen studies were eligible in this meta-analysis. Overall survival was not significantly different between FOLFIRINOX and GNP (HR 1.00, 95% CI 0.83-1.20, P = 0.990). However, the Western subgroup showed a higher survival benefit for FOLFIRINOX over GNP (HR 0.84, 95% CI 0.74-0.95, P = 0.006) whereas the Asian subgroup showed the survival benefit for GNP over FOLFIRINOX (HR 1.29, 95% CI 1.03-1.60, P = 0.030). Progression free survival was not significantly different between the two regimens in the Western subgroup (HR 1.01, 95% CI 0.84-1.20, P = 0.950) and the Asian subgroup (HR 1.13, 95% CI 0.97-1.33, P = 0.110). Occurrence of febrile neutropenia was significantly higher in FOLFIRINOX at both ethnic subgroups; however, that of peripheral neuropathy was significantly higher only in GNP of the Asian subgroup. Therefore, pharmacoethnicity might be a factor worth considering when deciding on a frontline chemotherapeutic regimen although the overall survival was not significantly different between FOLFIRINOX and GNP for metastatic PCs.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Jaehyeong Kim

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