Kendal Broadie

Department of Biological Sciences, Vanderbilt University

Affiliated withVanderbilt University Vanderbilt University and Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 23	2009
Publication title Cited by 6	2009
Publication title Cited by 7	2018
Publication title Cited by 7	2024

Other Publications

Article	Year
Developmental regulation of glutamate receptor field size by nonvesicular glutamate release. Nature neuroscience\| PubMed ID: 11753421	2002
Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 11891763	2002
Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development (Cambridge, England)\| PubMed ID: 12091308	2002
Response: meaningless minis? Trends in neurosciences\| PubMed ID: 12127747	2002
Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae. Journal of neurophysiology\| PubMed ID: 12163536	2002
Living synaptic vesicle marker: synaptotagmin-GFP. Genesis (New York, N.Y. : 2000)\| PubMed ID: 12324970	2002
Establishing and sculpting the synapse in Drosophila and C. elegans. Current opinion in neurobiology\| PubMed ID: 12367627	2002
The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. Current opinion in neurobiology\| PubMed ID: 12367628	2002
Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission. Traffic (Copenhagen, Denmark)\| PubMed ID: 12453153	2002
Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system. Journal of neurobiology\| PubMed ID: 12486708	2003
Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. Journal of neurobiology\| PubMed ID: 12532395	2003
Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission. Journal of neurophysiology\| PubMed ID: 12611964	2003
The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Current biology : CB\| PubMed ID: 12781128	2003
Techniques to dissect cellular and subcellular function in the Drosophila nervous system. Methods in cell biology\| PubMed ID: 12884693	2003
Axon pruning: an active role for glial cells. Current biology : CB\| PubMed ID: 15084298	2004
The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Developmental biology\| PubMed ID: 15183715	2004
The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Current biology : CB\| PubMed ID: 15242610	2004
Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. Journal of neurobiology\| PubMed ID: 15281071	2004
Ceramidase regulates synaptic vesicle exocytosis and trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15356190	2004
Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nature neuroscience\| PubMed ID: 15361878	2004
Synapse scaffolding: intersection of endocytosis and growth. Current biology : CB\| PubMed ID: 15458667	2004
The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15483129	2004
The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Current biology : CB\| PubMed ID: 15498496	2004
Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis. Molecular & cellular proteomics : MCP\| PubMed ID: 15634690	2005
Fathoming fragile X in fruit flies. Trends in genetics : TIG\| PubMed ID: 15680513	2005
Lipid regulation of the synaptic vesicle cycle. Nature reviews. Neuroscience\| PubMed ID: 15685219	2005
Translational complexity of the fragile x mental retardation protein: insights from the fly. Molecular cell\| PubMed ID: 15780932	2005
An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15788777	2005
Rolling blackout is required for synaptic vesicle exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16510714	2006
In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila. Journal of neuroscience methods\| PubMed ID: 17331586	2007
The ubiquitin-proteasome system postsynaptically regulates glutamatergic synaptic function. Molecular and cellular neurosciences\| PubMed ID: 17363264	2007
Proteasome function is required to maintain muscle cellular architecture. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 17523916	2007
Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation. Genes & development\| PubMed ID: 17901219	2007
Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A convergently regulate the synaptic ratio of ionotropic glutamate receptor subclasses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17989302	2007
CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature neuroscience\| PubMed ID: 18176560	2008
Roles of ubiquitination at the synapse. Biochimica et biophysica acta\| PubMed ID: 18222124	2008
Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Molecular and cellular neurosciences\| PubMed ID: 18280750	2008
Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development (Cambridge, England)\| PubMed ID: 18321984	2008
Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18354025	2008
Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18385325	2008
Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure. Development (Cambridge, England)\| PubMed ID: 18579676	2008
Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18579730	2008
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nature neuroscience\| PubMed ID: 18776892	2008
Two peptide transmitters co-packaged in a single neurosecretory vesicle. Peptides\| PubMed ID: 18848852	2008
Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein. Journal of neurophysiology\| PubMed ID: 19036865	2009
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell\| PubMed ID: 19041749	2008
Rolling blackout is required for bulk endocytosis in non-neuronal cells and neuronal synapses. Journal of cell science\| PubMed ID: 19066280	2009
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Molecular neurobiology\| PubMed ID: 19214804	2009
Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19235718	2009
Activity-dependent modulation of neural circuit synaptic connectivity. Frontiers in molecular neuroscience\| PubMed ID: 19668708	2009
Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Frontiers in neural circuits\| PubMed ID: 19738924	2009
Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain. Molecular bioSystems\| PubMed ID: 20379606	2010
Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. Disease models & mechanisms\| PubMed ID: 20442204	2010
The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. Journal of cell science\| PubMed ID: 20826458	2010
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiology of disease\| PubMed ID: 20843478	2011
Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. Development (Cambridge, England)\| PubMed ID: 20876658	2010
Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin. Traffic (Copenhagen, Denmark)\| PubMed ID: 21029287	2010
The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. The Journal of cell biology\| PubMed ID: 21041451	2010
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Frontiers in synaptic neuroscience\| PubMed ID: 21423490	2010
Glycosylated synaptomatrix regulation of trans-synaptic signaling. Developmental neurobiology\| PubMed ID: 21509945	2012
Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Developmental biology\| PubMed ID: 21596027	2011
Drosophila modeling of heritable neurodevelopmental disorders. Current opinion in neurobiology\| PubMed ID: 21596554	2011
Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Disease models & mechanisms\| PubMed ID: 21669931	2011
Extracellular matrix and its receptors in Drosophila neural development. Developmental neurobiology\| PubMed ID: 21688401	2011
Molecular and genetic analysis of the Drosophila model of fragile X syndrome. Results and problems in cell differentiation\| PubMed ID: 22009350	2012
In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Human molecular genetics\| PubMed ID: 22080836	2012
Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Developmental neurobiology\| PubMed ID: 22234957	2012
GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model. Neurobiology of disease\| PubMed ID: 24423648	2014
Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25253852	2014
Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model. Disease models & mechanisms\| PubMed ID: 25326312	2014
Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory. Development (Cambridge, England)\| PubMed ID: 25804740	2015
Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis. Development (Cambridge, England)\| PubMed ID: 26603384	2016
A fully automated Drosophila olfactory classical conditioning and testing system for behavioral learning and memory assessment. Journal of neuroscience methods\| PubMed ID: 26703418	2016
Neuron class-specific requirements for Fragile X Mental Retardation Protein in critical period development of calcium signaling in learning and memory circuitry. Neurobiology of disease\| PubMed ID: 26851502	2016
Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. Disease models & mechanisms\| PubMed ID: 26940433	2016
Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Human molecular genetics\| PubMed ID: 27466186	2016
Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit. Journal of neurophysiology\| PubMed ID: 27683892	2016
Neural Circuits: Reduced Inhibition in Fragile X Syndrome. Current biology : CB\| PubMed ID: 28441561	2017
Secreted tissue inhibitor of matrix metalloproteinase restricts -synaptic signaling to coordinate synaptogenesis. Journal of cell science\| PubMed ID: 28576972	2017
Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement. Current biology : CB\| PubMed ID: 28756946	2017
ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects. Scientific reports\| PubMed ID: 28819289	2017
Multifarious Functions of the Fragile X Mental Retardation Protein. Trends in genetics : TIG\| PubMed ID: 28826631	2017
Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling. Development (Cambridge, England)\| PubMed ID: 28860114	2017
Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28887386	2017
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis. Science signaling\| PubMed ID: 29114039	2017
Newly Identified Electrically Coupled Neurons Support Development of the Giant Fiber Model Circuit. eNeuro\| PubMed ID: 30627638	2018
Activity-Dependent Remodeling of Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30755492	2019
Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry. Neurobiology of disease\| PubMed ID: 30771457	2019
Carrier of Wingless (Cow) Regulation of Neuromuscular Junction Development. eNeuro\| PubMed ID: 32024666	2020
Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model. BMC biology\| PubMed ID: 32731855	2020
Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrate -synaptic signaling. Journal of cell science\| PubMed ID: 32788209	2020
FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry. Cell reports\| PubMed ID: 33053340	2020
Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 33402421	2021
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance. Nature communications\| PubMed ID: 33608547	2021
Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement. Journal of cell science\| PubMed ID: 33973638	2021
Temporally and Spatially Localized PKA Activity within Learning and Memory Circuitry Regulated by Network Feedback. eNeuro\| PubMed ID: 35301221	2022
RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development. Development (Cambridge, England)\| PubMed ID: 35394012	2022
Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome. Frontiers in cell and developmental biology\| PubMed ID: 35880195	2022
FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission. PLoS biology\| PubMed ID: 36701299	2023
Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36920921	2023
Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C. Disease models & mechanisms\| PubMed ID: 37815467	2023
Muscle cofilin alters neuromuscular junction postsynaptic development to strengthen functional neurotransmission. bioRxiv : the preprint server for biology\| PubMed ID: 38045306	2023
Use-dependent, untapped dual kinase signaling localized in brain learning circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 38267256	2024