Lingfeng Qin

Department of Surgery, Yale University School of Medicine

Affiliated withYale University School of Medicine Yale University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 17	2013
Publication title Cited by 7	2022
Publication title Cited by 1	2022

Other Publications

Article	Year
Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell stem cell\| PubMed ID: 32243809	2020
Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activ... Circulation research\| PubMed ID: 17656678	2007
Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17911610	2007
MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. The Journal of experimental medicine\| PubMed ID: 19064699	2008
Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection. The Journal of experimental medicine\| PubMed ID: 19075290	2008
JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. The Journal of biological chemistry\| PubMed ID: 19287004	2009
IFN-gamma primes intact human coronary arteries and cultured coronary smooth muscle cells to double-stranded RNA- and self-RNA-induced inflammatory responses by upregulating TLR3 and melanom... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20562257	2010
Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20720195	2010
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. The Journal of experimental medicine\| PubMed ID: 20733031	2010
AIP1 prevents graft arteriosclerosis by inhibiting interferon-Î³-dependent smooth muscle cell proliferation and intimal expansion. Circulation research\| PubMed ID: 21700930	2011
Transforming growth factor beta expression by human vascular cells inhibits interferon gamma production and arterial media injury by alloreactive memory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 21812925	2011
Activation of human vascular cells decreases their expression of transforming growth factor-beta. Atherosclerosis\| PubMed ID: 21862019	2011
FGF regulates TGF-Î² signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell reports\| PubMed ID: 23200853	2012
AIP1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23413429	2013
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. The Journal of clinical investigation\| PubMed ID: 23478407	2013
Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23493289	2013
SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function. Journal of the American College of Cardiology\| PubMed ID: 23994402	2014
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. The Journal of clinical investigation\| PubMed ID: 24401272	2014
Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. The Journal of experimental medicine\| PubMed ID: 24516119	2014
The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706887	2014
Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24903097	2014
Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Science signaling\| PubMed ID: 25249657	2014
Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26195760	2015
Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients. Circulation research\| PubMed ID: 26399469	2015
Endothelial-to-mesenchymal transition drives atherosclerosis progression. The Journal of clinical investigation\| PubMed ID: 26517696	2015
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nature communications\| PubMed ID: 26596471	2015
Blocking MHC class II on human endothelium mitigates acute rejection. JCI insight\| PubMed ID: 26900601	2016
Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO molecular medicine\| PubMed ID: 27189169	2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials\| PubMed ID: 27336184	2016
Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nature medicine\| PubMed ID: 27548575	2016
Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Scientific reports\| PubMed ID: 27634335	2016
Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 28213405	2017
Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28254817	2017
The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nature communications\| PubMed ID: 28569748	2017
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials\| PubMed ID: 28667900	2017
mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28751568	2017
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Circulation research\| PubMed ID: 28760777	2017
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells. Nature communications\| PubMed ID: 28775323	2017
Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials\| PubMed ID: 28942128	2017
Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature communications\| PubMed ID: 29802249	2018
AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 30471213	2019
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes. Nature communications\| PubMed ID: 31113953	2019
Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium. Circulation research\| PubMed ID: 31170059	2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature metabolism\| PubMed ID: 31572976	2019
Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production. Circulation\| PubMed ID: 31744330	2020
Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs. Cell stem cell\| PubMed ID: 31956039	2020
Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells. The Journal of clinical investigation\| PubMed ID: 32191642	2020
H19/TET1 axis promotes TGF-β signaling linked to endothelial-to-mesenchymal transition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32374060	2020
Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nature communications\| PubMed ID: 33495460	2021
CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 34670407	2021
Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation. Microvascular research\| PubMed ID: 34856183	2022
Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells. Circulation research\| PubMed ID: 35189711	2022
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35733256	2022