Vladimir I. Titorenko

Department of Biology, Concordia University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 84	2009
Publication title Cited by 39	2009
Publication title Cited by 3	2020
Publication title Cited by 4	2021

Other Publications

Article	Year
Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica. The Journal of cell biology\| PubMed ID: 11815635	2002
RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Physiological genomics\| PubMed ID: 12181365	2002
Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome. The Journal of cell biology\| PubMed ID: 14504266	2003
The peroxisome: orchestrating important developmental decisions from inside the cell. The Journal of cell biology\| PubMed ID: 14981090	2004
A new definition for the consensus sequence of the peroxisome targeting signal type 2. Journal of molecular biology\| PubMed ID: 15312767	2004
Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion. The Journal of cell biology\| PubMed ID: 15738267	2005
Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER. The Journal of cell biology\| PubMed ID: 16801391	2006
Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica. Biochimica et biophysica acta\| PubMed ID: 17023063	2006
Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through. FEMS yeast research\| PubMed ID: 17425673	2007
A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane. The Journal of cell biology\| PubMed ID: 17438077	2007
Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system. International review of cell and molecular biology\| PubMed ID: 19121819	2009
Effect of calorie restriction on the metabolic history of chronologically aging yeast. Experimental gerontology\| PubMed ID: 19539741	2009
A novel function of lipid droplets in regulating longevity. Biochemical Society transactions\| PubMed ID: 19754450	2009
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity ass... Aging\| PubMed ID: 20622262	2010
Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level. Aging\| PubMed ID: 20693605	2010
Peroxisome metabolism and cellular aging. Traffic (Copenhagen, Denmark)\| PubMed ID: 21083858	2011
In search of housekeeping pathways that regulate longevity. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21862878	2011
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget\| PubMed ID: 21992775	2011
Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia. Biochimica et biophysica acta\| PubMed ID: 22289388	2012
Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mec... Dose-response : a publication of International Hormesis Society\| PubMed ID: 22423230	2012
Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration. Frontiers in physiology\| PubMed ID: 22783207	2012
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22894934	2012
Integration of peroxisomes into an endomembrane system that governs cellular aging. Frontiers in physiology\| PubMed ID: 22936916	2012
The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary, and pharmacological anti-aging interventions. Frontiers in physiology\| PubMed ID: 23118730	2012
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging\| PubMed ID: 23553280	2013
A network of interorganellar communications underlies cellular aging. IUBMB life\| PubMed ID: 23818261	2013
Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity. Sub-cellular biochemistry\| PubMed ID: 23821148	2013
Mitochondrial membrane lipidome defines yeast longevity. Aging\| PubMed ID: 23924582	2013
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. PeerJ\| PubMed ID: 23940835	2013
Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death. Cell cycle (Georgetown, Tex.)\| PubMed ID: 24196447	2014
Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer. Antioxidants & redox signaling\| PubMed ID: 24382195	2014
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology. Redox biology\| PubMed ID: 24563847	2014
Metabolomic and lipidomic analyses of chronologically aging yeast. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25213255	2014
Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid. International journal of molecular sciences\| PubMed ID: 25238416	2014
Mechanism of liponecrosis, a distinct mode of programmed cell death. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25483081	2014
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25485579	2014
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system. Frontiers in physiology\| PubMed ID: 25566090	2014
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging and disease\| PubMed ID: 25657853	2015
Mechanisms by which different functional states of mitochondria define yeast longevity. International journal of molecular sciences\| PubMed ID: 25768339	2015
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25839782	2015
Longevity extension by phytochemicals. Molecules (Basel, Switzerland)\| PubMed ID: 25871373	2015
A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis. Oncotarget\| PubMed ID: 26636650	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Cell-Nonautonomous Mechanisms Underlying Cellular and Organismal Aging. International review of cell and molecular biology\| PubMed ID: 26811290	2016
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes. Oncotarget\| PubMed ID: 26918729	2016
Mitochondria operate as signaling platforms in yeast aging. Aging\| PubMed ID: 26928478	2016
Six plant extracts delay yeast chronological aging through different signaling pathways. Oncotarget\| PubMed ID: 27447556	2016
Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging. Frontiers in genetics\| PubMed ID: 27729926	2016
Empirical verification of evolutionary theories of aging. Aging\| PubMed ID: 27783562	2016
Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells. PeerJ\| PubMed ID: 27896021	2016
Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms. Frontiers in genetics\| PubMed ID: 27999589	2016
A laboratory test of evolutionary aging theories. Aging\| PubMed ID: 28325887	2017
Cell-autonomous mechanisms of chronological aging in the yeast . Microbial cell (Graz, Austria)\| PubMed ID: 28357241	2014
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast. Oncotarget\| PubMed ID: 28410198	2017
Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative medicine and cellular longevity\| PubMed ID: 28593023	2017
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated prote... Cellular signalling\| PubMed ID: 28923415	2017
Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae. Frontiers in bioscience (Landmark edition)\| PubMed ID: 28930594	2018
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state a... Oncotarget\| PubMed ID: 29050207	2017
Some Metabolites Act as Second Messengers in Yeast Chronological Aging. International journal of molecular sciences\| PubMed ID: 29543708	2018
Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative medicine and cellular longevity\| PubMed ID: 29636840	2018
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apo... Oncotarget\| PubMed ID: 29662634	2018
Yeast chronological aging is linked to cell cycle regulation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 29895227	2018
Molecular and Cellular Mechanisms of Aging and Age-related Disorders. International journal of molecular sciences\| PubMed ID: 30011889	2018
Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions. Oncotarget\| PubMed ID: 30405886	2018
Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay. Oncotarget\| PubMed ID: 30719227	2019
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells. International journal of molecular sciences\| PubMed ID: 31052375	2019
Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla. Frontiers in physiology\| PubMed ID: 31057428	2019
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies. International journal of molecular sciences\| PubMed ID: 31277345	2019
Mechanisms by which PE21, an extract from the white willow , delays chronological aging in budding yeast. Oncotarget\| PubMed ID: 31645900	2019
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast. Oncotarget\| PubMed ID: 32577164	2020
Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast. International journal of molecular sciences\| PubMed ID: 32630624	2020