Wolfgang Wiechert

Institute of Bio- and Geosciences, Forschungszentrum Juelich GmbH

Affiliated withForschungszentrum Juelich GmbH Forschungszentrum Jülich Bioeconomy Science Center (BioSC)

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 74	2013
Publication title Cited by 9	2017

Other Publications

Article	Year
Modeling and simulation: tools for metabolic engineering. Journal of biotechnology\| PubMed ID: 11792451	2002
An introduction to 13C metabolic flux analysis. Genetic engineering\| PubMed ID: 12416307	2002
MMT--a pathway modeling tool for data from rapid sampling experiments. In silico biology\| PubMed ID: 12611627	2002
Metabolic isotopomer labeling systems. Part II: structural flux identifiability analysis. Mathematical biosciences\| PubMed ID: 12711410	2003
New tools for mass isotopomer data evaluation in (13)C flux analysis: mass isotope correction, data consistency checking, and precursor relationships. Biotechnology and bioengineering\| PubMed ID: 14748080	2004
Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor. Biotechnology progress\| PubMed ID: 15176872	2004
Investigating the dynamic behavior of biochemical networks using model families. Bioinformatics (Oxford, England)\| PubMed ID: 15604106	2005
From stationary to instationary metabolic flux analysis. Advances in biochemical engineering/biotechnology\| PubMed ID: 15791936	2005
Emerging Corynebacterium glutamicum systems biology. Journal of biotechnology\| PubMed ID: 16406159	2006
Interpretation of metabolic flux maps by limitation potentials and constrained limitation sensitivities. Biotechnology and bioengineering\| PubMed ID: 16596665	2006
Experimental design principles for isotopically instationary 13C labeling experiments. Biotechnology and bioengineering\| PubMed ID: 16598793	2006
Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions. Metabolic engineering\| PubMed ID: 16890470	2006
Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments. Journal of biotechnology\| PubMed ID: 17207877	2007
Nondestructive and noncontact method for determining the spring constant of rectangular cantilevers. The Review of scientific instruments\| PubMed ID: 17477668	2007
Fluxomics: mass spectrometry versus quantitative imaging. Current opinion in plant biology\| PubMed ID: 17481942	2007
The thermodynamic meaning of metabolic exchange fluxes. Biophysical journal\| PubMed ID: 17526563	2007
The topology of metabolic isotope labeling networks. BMC bioinformatics\| PubMed ID: 17727715	2007
Visualizing regulatory interactions in metabolic networks. BMC biology\| PubMed ID: 17939866	2007
13C labeling experiments at metabolic nonstationary conditions: an exploratory study. BMC bioinformatics\| PubMed ID: 18366666	2008
Translating biochemical network models between different kinetic formats. Metabolic engineering\| PubMed ID: 19013536	2009
Modeling Languages for Biochemical Network Simulation: Reaction vs Equation Based Approaches. Advances in biochemical engineering/biotechnology\| PubMed ID: 20309675	2010
Stationary versus non-stationary (13)C-MFA: a comparison using a consistent dataset. Journal of biotechnology\| PubMed ID: 20638432	2011
Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile. Current opinion in biotechnology\| PubMed ID: 21353523	2011
Visualizing multi-omics data in metabolic networks with the software Omix: a case study. Bio Systems\| PubMed ID: 21575673	2011
The benefits of being transient: isotope-based metabolic flux analysis at the short time scale. Applied microbiology and biotechnology\| PubMed ID: 21732247	2011
Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum. Applied and environmental microbiology\| PubMed ID: 21784914	2011
Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of ¹³C metabolic flux analysis. Biotechnology and bioengineering\| PubMed ID: 22012626	2012
Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells. Nature protocols\| PubMed ID: 22036884	2011
Tailoring a stabilized variant of hydroxynitrile lyase from Arabidopsis thaliana. Chembiochem : a European journal of chemical biology\| PubMed ID: 22378361	2012
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a chip\| PubMed ID: 22511122	2012
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. Biotechnology and bioengineering\| PubMed ID: 22890752	2013
Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. Microbial cell factories\| PubMed ID: 22963408	2012
13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis. Bioinformatics (Oxford, England)\| PubMed ID: 23110970	2013
Influence of Organic Solvents on Enzymatic Asymmetric Carboligations. Advanced synthesis & catalysis\| PubMed ID: 23349644	2012
Combined fluxomics and transcriptomics analysis of glucose catabolism via a partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H. Applied and environmental microbiology\| PubMed ID: 23377928	2013
Metabolic isotopomer labeling systems. Part III: path tracing. Mathematical biosciences\| PubMed ID: 23507460	2013
Isotopically non-stationary metabolic flux analysis: complex yet highly informative. Current opinion in biotechnology\| PubMed ID: 23623747	2013
Simultaneous utilization of glucose and gluconate in Penicillium chrysogenum during overflow metabolism. Biotechnology and bioengineering\| PubMed ID: 23775209	2013
13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis. Chemistry & biology\| PubMed ID: 23911587	2013
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnology and bioengineering\| PubMed ID: 23996851	2013
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes. Journal of microbiological methods\| PubMed ID: 24041615	2013
Assessment of robustness against dissolved oxygen/substrate oscillations for C. glutamicum DM1933 in two-compartment bioreactor. Bioprocess and biosystems engineering\| PubMed ID: 24218302	2013
Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum. Microbial cell factories\| PubMed ID: 24410842	2014
Single-cell microfluidics: opportunity for bioprocess development. Current opinion in biotechnology\| PubMed ID: 24642389	2014
Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer. Microbial cell factories\| PubMed ID: 24661794	2014
Quantitative metabolomics: a phantom? Trends in biotechnology\| PubMed ID: 24708998	2014
Error propagation analysis for quantitative intracellular metabolomics. Metabolites\| PubMed ID: 24957773	2012
Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum. Bioprocess and biosystems engineering\| PubMed ID: 24981020	2014
An evaluation of genetically encoded FRET-based biosensors for quantitative metabolite analyses in vivo. Journal of biotechnology\| PubMed ID: 25107505	2014
Chassis organism from Corynebacterium glutamicum--a top-down approach to identify and delete irrelevant gene clusters. Biotechnology journal\| PubMed ID: 25139579	2015
Visual workflows for 13C-metabolic flux analysis. Bioinformatics (Oxford, England)\| PubMed ID: 25297067	2015
Engineering of Corynebacterium glutamicum for minimized carbon loss during utilization of D-xylose containing substrates. Journal of biotechnology\| PubMed ID: 25304460	2014
Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT. Journal of proteomics\| PubMed ID: 25451015	2015
How to measure metabolic fluxes: a taxonomic guide for (13)C fluxomics. Current opinion in biotechnology\| PubMed ID: 25531408	2015
Bioprocess automation on a Mini Pilot Plant enables fast quantitative microbial phenotyping. Microbial cell factories\| PubMed ID: 25888907	2015
The effect of composition on diffusion of macromolecules in a crowded environment. Physical biology\| PubMed ID: 26020120	2015
Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations. Molecular microbiology\| PubMed ID: 26235130	2015
Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics (Oxford, England)\| PubMed ID: 26261223	2015
Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level. Lab on a chip\| PubMed ID: 26345659	2015
Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 26348020	2015
Cutting the Gordian Knot: Identifiability of anaplerotic reactions in Corynebacterium glutamicum by means of (13) C-metabolic flux analysis. Biotechnology and bioengineering\| PubMed ID: 26375179	2016
(13)C Tracers for Glucose Degrading Pathway Discrimination in Gluconobacter oxydans 621H. Metabolites\| PubMed ID: 26404385	2015
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester. PloS one\| PubMed ID: 26513257	2015
Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression. Chembiochem : a European journal of chemical biology\| PubMed ID: 26677142	2016
A scientific workflow framework for (13)C metabolic flux analysis. Journal of biotechnology\| PubMed ID: 26721184	2016
Discrete-continuous reaction-diffusion model with mobile point-like sources and sinks. The European physical journal. E, Soft matter\| PubMed ID: 26830760	2016
Automation of a Nile red staining assay enables high throughput quantification of microalgal lipid production. Microbial cell factories\| PubMed ID: 26861538	2016
μMORE: A microfluidic magnetic oscillation reactor for accelerated parameter optimization in biocatalysis. Journal of biotechnology\| PubMed ID: 27288595	2016
Design and validation of a parallelized micro-photobioreactor enabling phototrophic bioprocess development at elevated throughput. Biotechnology and bioengineering\| PubMed ID: 27424867	2017
Time-resolved, single-cell analysis of induced and programmed cell death via non-invasive propidium iodide and counterstain perfusion. Scientific reports\| PubMed ID: 27580964	2016
Metabolic profile of 1,5-diaminopentane producing Corynebacterium glutamicum under scale-down conditions: Blueprint for robustness to bioreactor inhomogeneities. Biotechnology and bioengineering\| PubMed ID: 27641904	2017
Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments. PloS one\| PubMed ID: 27661996	2016
A Toolbox of Genetically Encoded FRET-Based Biosensors for Rapid l-Lysine Analysis. Sensors (Basel, Switzerland)\| PubMed ID: 27690044	2016
Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum. Microbial cell factories\| PubMed ID: 27927208	2016
Comparative evaluation of phototrophic microtiter plate cultivation against laboratory-scale photobioreactors. Bioprocess and biosystems engineering\| PubMed ID: 28101644	2017
A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design. Biotechnology for biofuels\| PubMed ID: 28163783	2017
Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level. Microbial biotechnology\| PubMed ID: 28371389	2017
Fast and reliable strain characterization of Streptomyces lividans through micro-scale cultivation. Biotechnology and bioengineering\| PubMed ID: 28436005	2017
Miniaturized and automated adaptive laboratory evolution: Evolving Corynebacterium glutamicum towards an improved d-xylose utilization. Bioresource technology\| PubMed ID: 28552568	2017
Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity. Metabolic engineering\| PubMed ID: 28645641	2017
To be certain about the uncertainty: Bayesian statistics for 13 C metabolic flux analysis. Biotechnology and bioengineering\| PubMed ID: 28695999	2017
Corynebacterium glutamicum Chassis C1*: Building and Testing a Novel Platform Host for Synthetic Biology and Industrial Biotechnology. ACS synthetic biology\| PubMed ID: 28803482	2017
pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation. Journal of biotechnology\| PubMed ID: 28837821	2017
Laboratory scale photobiotechnology - Current trends and future perspectives. FEMS microbiology letters\| PubMed ID: 29126108	2017
Automated growth rate determination in high-throughput microbioreactor systems. BMC research notes\| PubMed ID: 29178966	2017