Norbert Perrimon

Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute

Affiliated withHarvard Medical School and Howard Hughes Medical Institute Harvard Medical School Howard Hughes Medical Institute

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2009
Publication title Cited by 9	2011

Other Publications

Article	Year
Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development (Cambridge, England)\| PubMed ID: 11782411	2002
Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes & development\| PubMed ID: 11825878	2002
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development (Cambridge, England)\| PubMed ID: 11861468	2002
CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Molecular and cellular biology\| PubMed ID: 11865058	2002
Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Current biology : CB\| PubMed ID: 11937021	2002
The promise and perils of Wnt signaling through beta-catenin. Science (New York, N.Y.)\| PubMed ID: 12040179	2002
Cellular processes associated with germ band retraction in Drosophila. Developmental biology\| PubMed ID: 12142018	2002
Molecular mechanisms of epithelial morphogenesis. Annual review of cell and developmental biology\| PubMed ID: 12142280	2002
Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development (Cambridge, England)\| PubMed ID: 12183376	2002
Hedgehog signal transduction: recent findings. Current opinion in genetics & development\| PubMed ID: 12200154	2002
Unconventional ways to travel. Nature cell biology\| PubMed ID: 12205482	2002
Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis (New York, N.Y. : 2000)\| PubMed ID: 12324947	2002
Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. Biochimica et biophysica acta\| PubMed ID: 12417410	2002
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12424225	2003
Sequential activation of signaling pathways during innate immune responses in Drosophila. Developmental cell\| PubMed ID: 12431377	2002
A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron\| PubMed ID: 12441051	2002
The Jak/STAT pathway in model organisms: emerging roles in cell movement. Developmental cell\| PubMed ID: 12479803	2002
Roles of myosin phosphatase during Drosophila development. Development (Cambridge, England)\| PubMed ID: 12505998	2003
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nature cell biology\| PubMed ID: 12510194	2003
The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics\| PubMed ID: 12524343	2002
Tailoring the genome: the power of genetic approaches. Nature genetics\| PubMed ID: 12610537	2003
Retraction of the Drosophila germ band requires cell-matrix interaction. Genes & development\| PubMed ID: 12629042	2003
The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila. Development (Cambridge, England)\| PubMed ID: 12702654	2003
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Developmental biology\| PubMed ID: 12812783	2003
Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. The EMBO journal\| PubMed ID: 12853478	2003
Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development (Cambridge, England)\| PubMed ID: 12900463	2003
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (Cambridge, England)\| PubMed ID: 12917292	2003
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Developmental cell\| PubMed ID: 12967563	2003
Developmental roles of heparan sulfate proteoglycans in Drosophila. Glycoconjugate journal\| PubMed ID: 12975617	2002
Apicobasal polarization: epithelial form and function. Current opinion in cell biology\| PubMed ID: 14644201	2003
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics\| PubMed ID: 14668372	2003
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nature immunology\| PubMed ID: 14691479	2004
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (New York, N.Y.)\| PubMed ID: 14764878	2004
Wingless, hedgehog and heparan sulfate proteoglycans. Development (Cambridge, England)\| PubMed ID: 15148297	2004
Temperature-sensitive control of protein activity by conditionally splicing inteins. Nature biotechnology\| PubMed ID: 15184905	2004
The roles of JAK/STAT signaling in Drosophila immune responses. Immunological reviews\| PubMed ID: 15199955	2004
The PDGF/VEGF receptor controls blood cell survival in Drosophila. Developmental cell\| PubMed ID: 15239955	2004
Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. Developmental biology\| PubMed ID: 15302597	2004
Genome-wide high-throughput screens in functional genomics. Current opinion in genetics & development\| PubMed ID: 15380236	2004
Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Developmental cell\| PubMed ID: 15469842	2004
Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene\| PubMed ID: 15517017	2004
The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Developmental biology\| PubMed ID: 15531366	2004
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS biology\| PubMed ID: 15547975	2004
High-throughput RNA interference screens in Drosophila tissue culture cells. Methods in enzymology\| PubMed ID: 15644175	2005
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes & development\| PubMed ID: 15713840	2005
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (Cambridge, England)\| PubMed ID: 15772135	2005
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (New York, N.Y.)\| PubMed ID: 15774762	2005
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (New York, N.Y.)\| PubMed ID: 15817814	2005
Drosophila Wnt/Fz pathways. Science's STKE : signal transduction knowledge environment\| PubMed ID: 15886387	2005
Function of the ETS transcription factor Yan in border cell migration. Development (Cambridge, England)\| PubMed ID: 16014514	2005
Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (New York, N.Y.)\| PubMed ID: 16020693	2005
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (New York, N.Y.)\| PubMed ID: 16020694	2005
Super-size flies. Cell metabolism\| PubMed ID: 16054074	2005
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes & development\| PubMed ID: 16055650	2005
Norbert Perrimon. Current biology : CB\| PubMed ID: 16059997	2005
Heparan sulphate proteoglycans: the sweet side of development. Nature reviews. Molecular cell biology\| PubMed ID: 16072037	2005
Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E. Cellular signalling\| PubMed ID: 16129580	2006
BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental cell\| PubMed ID: 16256740	2005
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nature genetics\| PubMed ID: 16311596	2005
Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature\| PubMed ID: 16340959	2006
FlyRNAi: the Drosophila RNAi screening center database. Nucleic acids research\| PubMed ID: 16381918	2006
Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature\| PubMed ID: 16452979	2006
High-throughput RNAi screening in cultured cells: a user's guide. Nature reviews. Genetics\| PubMed ID: 16607398	2006
Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Current biology : CB\| PubMed ID: 16782008	2006
High-throughput approaches to dissecting MAPK signaling pathways. Methods (San Diego, Calif.)\| PubMed ID: 16844385	2006
The emergence of geometric order in proliferating metazoan epithelia. Nature\| PubMed ID: 16900102	2006
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nature methods\| PubMed ID: 16964256	2006
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature methods\| PubMed ID: 16990807	2006
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene expression patterns : GEP\| PubMed ID: 17008134	2007
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS pathogens\| PubMed ID: 17040126	2006
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature\| PubMed ID: 17086199	2006
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug discovery today\| PubMed ID: 17198970	2007
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics\| PubMed ID: 17244760	2007
Genetic screening for signal transduction in the era of network biology. Cell\| PubMed ID: 17254958	2007
Do-it-yourself RNAi made easy? Nature methods\| PubMed ID: 17396126	2007
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17517653	2007
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (New York, N.Y.)\| PubMed ID: 17588932	2007
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nature protocols\| PubMed ID: 17853882	2007
A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. Genome biology\| PubMed ID: 17903264	2007
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17989227	2007
Drosophila and the genetics of the internal milieu. Nature\| PubMed ID: 17994083	2007
SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Developmental cell\| PubMed ID: 18061565	2007
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nature methods\| PubMed ID: 18066071	2008
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nature methods\| PubMed ID: 18084299	2008
Cellular phenotype recognition for high-content RNA interference genome-wide screening. Journal of biomolecular screening\| PubMed ID: 18227224	2008
ESCRT factors restrict mycobacterial growth. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287038	2008
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nature genetics\| PubMed ID: 18311141	2008
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development (Cambridge, England)\| PubMed ID: 18359903	2008
An endogenous small interfering RNA pathway in Drosophila. Nature\| PubMed ID: 18463631	2008
Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC bioinformatics\| PubMed ID: 18534020	2008
An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling. Journal of biomedical informatics\| PubMed ID: 18547870	2009
Identification of neural outgrowth genes using genome-wide RNAi. PLoS genetics\| PubMed ID: 18604272	2008
Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development (Cambridge, England)\| PubMed ID: 18614578	2008
Developmental biology: Our fly cousins' gut. Nature\| PubMed ID: 18668098	2008
Matter arising: off-targets and genome-scale RNAi screens in Drosophila. Fly\| PubMed ID: 18705022	2007
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (New York, N.Y.)\| PubMed ID: 18927396	2008
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Molecular cell\| PubMed ID: 19026789	2008
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development (Cambridge, England)\| PubMed ID: 19211682	2009
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Disease models & mechanisms\| PubMed ID: 19380309	2009
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics\| PubMed ID: 19487563	2009
RNAiCut: automated detection of significant genes from functional genomic screens. Nature methods\| PubMed ID: 19564846	2009
Droplet microfluidic technology for single-cell high-throughput screening. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19617544	2009
The twin spot generator for differential Drosophila lineage analysis. Nature methods\| PubMed ID: 19633664	2009
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (New York, N.Y.)\| PubMed ID: 19635780	2009
Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics\| PubMed ID: 19720858	2009
Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. Nature protocols\| PubMed ID: 19798083	2009
Homeostasis in infected epithelia: stem cells take the lead. Cell host & microbe\| PubMed ID: 19837370	2009
Hierarchical rules for Argonaute loading in Drosophila. Molecular cell\| PubMed ID: 19917252	2009
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19934041	2009
Use of a label-free quantitative platform based on MS/MS average TIC to calculate dynamics of protein complexes in insulin signaling. Journal of biomolecular techniques : JBT\| PubMed ID: 19949701	2009
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics\| PubMed ID: 20100940	2010
Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Genome research\| PubMed ID: 20144944	2010
Genomic screening with RNAi: results and challenges. Annual review of biochemistry\| PubMed ID: 20367032	2010
Realizing the promise of RNAi high throughput screening. Developmental cell\| PubMed ID: 20412765	2010
In vivo RNAi: today and tomorrow. Cold Spring Harbor perspectives in biology\| PubMed ID: 20534712	2010
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS genetics\| PubMed ID: 20585550	2010
Steroids make you bigger? Fat chance says Myc. Cell metabolism\| PubMed ID: 20620990	2010
A genome-wide gene function prediction resource for Drosophila melanogaster. PloS one\| PubMed ID: 20711346	2010
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20729470	2010
作为一种模型系统研究自噬的果蝇。 Seminars in immunopathology\| PubMed ID: 20798940	2010
Identification of adult midgut precursors in Drosophila. Gene expression patterns : GEP\| PubMed ID: 20804858	2011
Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis. Development (Cambridge, England)\| PubMed ID: 20940225	2010
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (Cambridge, England)\| PubMed ID: 21098564	2010
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell\| PubMed ID: 21111239	2010
Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS genetics\| PubMed ID: 21124995	2010
All for one, and one for all: the clonality of the intestinal stem cell niche. F1000 biology reports\| PubMed ID: 21173846	2010
The transcriptional diversity of 25 Drosophila cell lines. Genome research\| PubMed ID: 21177962	2011
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome research\| PubMed ID: 21177969	2011
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (New York, N.Y.)\| PubMed ID: 21177974	2010
The developmental transcriptome of Drosophila melanogaster. Nature\| PubMed ID: 21179090	2011
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 21197652	2011
A genome-wide RNAi screen identifies core components of the Gâ‚‚-M DNA damage checkpoint. Science signaling\| PubMed ID: 21205937	2011
False negative rates in Drosophila cell-based RNAi screens: a case study. BMC genomics\| PubMed ID: 21251254	2011
Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases. Proceedings / Annual IEEE International Symposium on Bioinformatics and Bioengineering (BIBE). IEEE International Symposium on Bioinformatics and Bioengineering\| PubMed ID: 21278820	2007
Control of the mitotic cleavage plane by local epithelial topology. Cell\| PubMed ID: 21295702	2011
Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Human molecular genetics\| PubMed ID: 21300695	2011
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nature methods\| PubMed ID: 21460824	2011
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome research\| PubMed ID: 21685129	2011
Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis. Developmental cell\| PubMed ID: 21763605	2011
An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC bioinformatics\| PubMed ID: 21880147	2011
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. The Journal of cell biology\| PubMed ID: 21893601	2011
RNAi screening: new approaches, understandings, and organisms. Wiley interdisciplinary reviews. RNA\| PubMed ID: 21953743	2011
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Science signaling\| PubMed ID: 22028469	2011
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. Nucleic acids research\| PubMed ID: 22067456	2012
The era of systems developmental biology. Current opinion in genetics & development\| PubMed ID: 22079435	2011
Stringent Analysis of Gene Function and Protein-Protein Interactions Using Fluorescently Tagged Genes. Genetics\| PubMed ID: 22174071	2011