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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20th, 2023
*1,2,3,4,5, *1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5
1Icahn School of Medicine at Mount Sinai, 2Black Family Stem Cell Institute at Mount Sinai, 3Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, 4Friedman Brain Institute at Mount Sinai, 5Nash Family Department of Neuroscience at Mount Sinai
* These authors contributed equally

Summary
Automatic Translation

血脑屏障（BBB）在维持稳定和健康的大脑环境方面起着至关重要的作用。血脑屏障功能障碍与许多神经系统疾病有关。我们开发了一种 3D 干细胞衍生的 BBB 模型，用于研究脑血管病理学、BBB 完整性以及 BBB 如何被遗传和疾病改变。

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