毛囊是皮肤中一种高度复杂的附属器官，包含多种细胞类型。毛囊在生物体生命周期中持续经历生长和退化循环，其生长依赖于特定的干细胞。本文讨论了利用基因和干细胞靶向毛囊以改变其特性，特别是毛干性质的方法。描述了毛囊递送系统，例如用于基因治疗的脂质体和病毒载体。还探讨了毛囊干细胞的特性，尤其是其多能性。
毛囊是皮肤中一种高度复杂的附属器官，包含多种细胞类型。毛囊在生物体生命周期中持续经历生长和退化循环，其生长依赖于特定的干细胞。本文讨论了利用基因和干细胞靶向毛囊以改变其特性，特别是毛干性质的方法。描述了毛囊递送系统，例如用于基因治疗的脂质体和病毒载体。还探讨了毛囊干细胞的特性，尤其是其多能性。
毛囊中含有多种细胞类型，包括形成毛干的毛球细胞、在毛囊周期生长期（anagen 期）早期能够启动毛干形成的干细胞，以及具有多向分化潜能的多能干细胞——后者虽参与毛囊的生长，但也有潜力分化为非毛囊细胞，例如神经元。本文讨论了毛囊的这些特性。毛囊中各种细胞类型是基因治疗的潜在靶点。此外，还探讨了利用病毒载体或脂质体将基因靶向递送至毛囊内不同细胞类型的基因递送系统及其所获得的结果。
有关使用离体病毒转导在毛囊中实现GFP靶向表达的更多信息，请访问 Springer Protocols。
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申请许可A correction was made to: Targeted expression of GFP in the hair follicle using ex vivo viral transduction. A revised abstract was republished due to a publisher error. The correct abstract is:
There are many cell types in the hair follicle, including hair matrix cells which form the hair shaft and stem cells which can initiate the hair shaft during early anagen, the growth phase of the hair cycle, as well as pluripotent stem cells that play a role in hair follicle growth but have the potential to differentiate to non-follicle cells such as neurons. These properties of the hair follicle are discussed. The various cell types of the hair follicle are potential targets for gene therapy. Gene delivery system for the hair follicle using viral vectors or liposomes for gene targeting to the various cell types in the hair follicle and the results obtained are also discussed.
This replaced:
The hair follicle is a highly complex appendage of the skin containing a multiplicity of cell types. The follicle undergoes constant cycling through the life of the organism including growth and resorption with growth dependent on specific stem cells. The targeting of the follicle by genes and stem cells to change its properties, in particular, the nature of the hair shaft is, discussed. Hair follicle delivery systems are described, such as liposomes and viral vectors for gene therapy. The nature of the hair follicle stem cells is discussed, in particular, its pluripotency.