Ophthalmic Ultrasound
Ophthalmic Ultrasound - Related Videos
01:23
Ophthalmic Drug Delivery Systems
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2026
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
02:51
An Ultrasound-Assisted Delivery of Antibodies in a Mouse Model
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2025
This video demonstrates a procedure of ultrasound-assisted antibody delivery in a mouse model. Retro-orbitally injected microbubbles oscillate under ultrasound, creating a transient disruption in the blood-brain barrier, permitting labeled antibodies to enter the brain.
07:12
Diagnostic Ultrasound Imaging of Mouse Diaphragm Function
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Cited by 7 •
2014
Diagnostic ultrasound imaging has proven to be effective in diagnosing various respiratory diseases in human and animal subjects. We demonstrate a comprehensive ultrasound protocol utilized by Dr. Zuo's lab to analyze diaphragm kinetics specifically in mouse models. This is also a non-invasive research technique which can provide quantitative information on mouse respiratory muscle function.
14:20
High-frequency Ultrasound Imaging of the Abdominal Aorta
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2023
Source: Amelia R. Adelsperger, Evan H. Phillips, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana High-frequency ultrasound systems are used to acquire high resolution images. Here, the use of a state-of-the-art system will be demonstrated to image the morphology and hemodynamics of small pulsatile arteries and veins found in mice and rats. Ultrasound is a relatively inexpensive, portable, and versatile method for the noninvasive...
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
FAQs
Image formation depends on how strongly ocular tissues differ in acoustic impedance, meaning their resistance to the passage of sound. When a pulse reaches a tissue boundary, part of the sound returns as an echo. Differences in echo strength and timing allow software to distinguish boundaries and represent the relative arrangement of structures within the eye and orbit.
Real-time two-dimensional imaging shows the spatial relationships among ocular and surrounding orbital structures as the examination proceeds. These images support structural measurements and allow researchers to document anatomical changes rather than relying only on behavioral observations. Repeated visualization can therefore help relate changes in eye structure to visual performance or other measured outcomes.
Ophthalmic ultrasound remains useful when optical examination cannot adequately visualize the eye or surrounding orbital structures. Because it uses sound-based imaging rather than requiring extensive tissue disruption, researchers can obtain anatomical information while preserving the broader experimental subject. This is particularly relevant when structural assessment must accompany functional or behavioral testing.
The process begins by positioning a probe so that it can send sound pulses through the ocular tissues. Returning echoes are collected as they reflect from tissue boundaries, and software converts their timing and strength into a two-dimensional image. Researchers can then examine the displayed anatomy and record structural measurements relevant to the study.
In animal research, ophthalmic ultrasound can document ocular development, injury, disease-related anatomical changes, and responses to treatment. These uses allow investigators to track structural status alongside other observations without extensive tissue disruption. The resulting measurements can provide anatomical context for interpreting changes in visual function, performance, or behavior across an experiment.
Behavioral studies can use ophthalmic ultrasound to pair anatomical measurements with assessments of visual function and observed behavior. For example, structural differences or changes identified in an animal model may be considered alongside performance-related findings. This combined approach helps investigators examine whether ocular development, injury, disease, or treatment outcomes correspond with changes in visual behavior.