Non-contact Dispensing
Non-contact Dispensing - Related Videos
10:14
Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells
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Cited by 9 •
2016
This protocol describes a bioprinting methodology using an automated robotic depositing system that incorporates etched topographical guidance cues with the precision deposition of a cell bearing hydrogel bioink. The printed cells are directly delivered to the etched features and are able to sense and orientate with them.
07:05
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
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Cited by 6 •
2015
A Cartesian bioprinter was designed and fabricated to allow multi-material deposition in precise, reproducible geometries, while also allowing control of environmental factors. Utilizing the three-dimensional bioprinter, complex and viable constructs may be printed and easily reproduced.
08:06
Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
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Cited by 1 •
2016
Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.
01:13
Contact Angle
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2023
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces. The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive force...
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Cited by 2 •
2022
Contact hypersensitivity (CHS) is a murine experimental model of allergic contact dermatitis (ACD). CHS is based on sensitization with reactive hapten by painting the shaved skin of the chest and abdomen, with a subsequent ear skin challenge with a diluted hapten, causing a swelling reaction that is assessed in various ways.
FAQs
Droplet ejection depends on a controlled pressure pulse generated by an actuator such as a piezoelectric, acoustic, or thermal system. The pulse drives liquid through an orifice, while the dispensing head positions the resulting droplet on the target. This coupling of actuation, pressure, and positioning supports precise delivery at nanoliter scale in biochemical workflows.
Keeping the dispensing hardware away from the receiving surface limits direct transfer between the delivery system and the destination. That separation helps reduce contamination and sample carryover, which is especially valuable when many biochemical reactions or analytical positions are prepared sequentially. The approach therefore supports cleaner automated workflows without requiring contact between the dispenser and target.
Nanoliter-scale droplets allow reaction mixtures to be prepared with smaller reagent volumes than larger-scale formats. Reduced volume helps conserve valuable samples while enabling many reaction positions to be arranged for rapid assay development. In biochemistry, this supports miniaturized workflows such as reaction preparation, microarray production, and analytical plate setup.
A dispensing head receives the liquid, generates a controlled pressure pulse, ejects a droplet through its orifice, and positions that droplet on the selected target. Automated control can repeat this process across reaction locations or analytical formats. The workflow is organized around accurate placement, small-volume delivery, and consistent preparation of biochemical samples.
The method can prepare reaction mixtures, create microarrays, and fill analytical plates with precisely positioned droplets. These applications benefit from rapid delivery, reduced sample consumption, and limited contact between dispensing hardware and receiving surfaces. Such capabilities make the approach useful for high-throughput biochemical experimentation and for developing diagnostic workflows.
Non-contact Dispensing can provide reproducible, position-controlled delivery while conserving valuable reagents and samples. Its compatibility with rapid assay miniaturization supports high-throughput experimentation, where many biochemical conditions or reactions must be prepared efficiently. The same features contribute to research and diagnostic development by enabling automated preparation of consistent reaction and analytical formats.