3d Biomaterial Scaffolds
3d Biomaterial Scaffolds - Related Videos
07:04
Preparation of 3D Fibrin Scaffolds for Stem Cell Culture Applications
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Cited by 52 •
2012
This work details the preparation of 3D fibrin scaffolds for culturing and differentiating plutipotent stem cells. Such scaffolds can be used to screen the effects of various biological compounds on stem cell behavior as well as modified to contain drug delivery systems.
07:58
Electrospinning of Silk Biomaterials
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2023
Silk fibers have been processed and used to create fabrics and threads for centuries. However, the solubilizing of silk fibers, thereby turning it into a versatile pre-polymer solution is a much newer technology. Solubilized silk can be processed in many different ways to create a biocompatible material with controllable mechanical properties. This video introduces the processing of silk from silk worm cocoons, and shows how the silk solution can be used to create a fiber mat via...
09:41
Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
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Cited by 9 •
2020
Stroke is a global issue with minimal treatment options and no current clinical therapy for regenerating the lost brain tissue. Here we describe methods for creating precise photothrombotic stroke in the motor cortex of rodents and subsequent injection of hydrogel biomaterials to study their effects on tissue regeneration after stroke.
08:06
Interview: Bioreactors and Surfaced-Modified 3D-Scaffolds for Stem Cell Research
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2008
In the past many in vitro culture systems -- mainly monolayer cultures -- often suffered from the disadvantage that differentiated primary cells had a relatively short life-span and de-differentiated during culture. As a consequence, most of their organ-specific functions were lost rapidly. Thus, in order to reproduce better conditions for these cells in vitro, modifications and adaptations have been made to conventional monolayer cultures.
07:44
Overview of Biomaterials
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2023
Biomaterials are materials engineered to interact favorably with biological organisms or molecules. These materials can be derived from or produced by an organism, or can even be a synthesized polymer. Engineers use these novel materials in a wide range of applications, such as tissue engineering, biosensing and drug delivery. This video introduces common biologically derived materials, and provides examples of common techniques used to process them. Key challenges in the field are discussed,...
FAQs
Pore architecture regulates how cells attach, grow, and organize within a scaffold. Interconnected pores also support the movement of nutrients and oxygen into the construct while allowing metabolic waste to leave. By tuning these features, researchers can influence cell–material interactions and create environments that better support tissue formation, repair, or physiologically relevant laboratory models.
The degradation rate determines how long a scaffold remains available as tissue develops. Matching degradation with new tissue formation helps the construct provide support during the needed period without losing its intended function too early or persisting beyond the regenerative process. This relationship is therefore an important design consideration in tissue engineering and regenerative medicine.
Natural polymers, synthetic polymers, ceramics, and composites provide different options for tuning scaffold composition and cell–material interactions. Material selection can also be coordinated with the desired degradation behavior and structural design. In bioengineering, these choices help researchers adapt scaffolds to applications ranging from tissue repair to drug delivery and in vitro disease modeling.
Researchers fabricate these constructs using methods such as 3D printing, electrospinning, and freeze-drying. Each method provides an approach for creating a three-dimensional structure from selected polymers, ceramics, or composite materials. Choosing among them allows scaffold development to be aligned with the intended architecture, composition, and use in tissue engineering, regenerative medicine, or laboratory models.
In tissue engineering and regenerative medicine, scaffolds provide a structured environment that supports cell attachment, growth, and organization during tissue formation or repair. Their composition, pore connectivity, and degradation behavior can be adjusted to guide biological responses and transport conditions. These properties make them useful for developing constructs intended to support implant and therapeutic development.
Scaffolds extend beyond tissue repair by providing three-dimensional systems for drug delivery and disease research. Their tunable composition and interconnected pores can help create more physiologically relevant environments than simpler model systems. In bioengineering, such constructs support the study of cell behavior and therapeutic development while reflecting aspects of tissue organization, transport, and material interaction.