Fiber Features
Fiber Features - Related Videos
08:28
Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
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Cited by 6 •
2017
A protocol for the microfluidic spinning and microstructure characterization of regenerated silk fibroin monofilament is presented.
03:55
In Vivo Single-Fiber Recording of Sciatic Nerve C-Fibers in Rats
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2025
This video demonstrates a single-fiber recording of C-fiber nerve conduction in rats. An anesthetized rat is incised to expose the sciatic nerve, which provides sensory and motor supply to the lower limbs. The individual C-fibers are then exposed. Electrical stimulation is provided using stimulus electrodes implanted in the foot, and a response is recorded from a single nerve fiber.
16:23
Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
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Cited by 32 •
2017
The purpose of this study is to show each step of the fiber dissection technique on human cadaveric brains, the 3D documentation of these dissections, and the diffusion tensor imaging of the anatomically dissected fiber pathways.
05:37
Visualization of Mitochondria within Intraepidermal Nerve Fibers
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2025
Source: Hamid, H. S., et al. Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers. J. Vis. Exp. (2017) This video demonstrates the method for visualizing nerve-specific mitochondria using three-dimensional imaging. It outlines the process of acquiring sequential scans of pre-labeled intraepidermal nerve fibers and generating 3D surface images to isolate and display mitochondria in relation to nerve structures.
05:42
Visual Search for Features and Conjunctions
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University How do people find objects in cluttered visual scenes? Think, for example, of looking for keys on a messy desk, finding the ripest-looking fruit at the grocery store, locating your car when you can’t quite remember where you parked it, or finding an old friend at an airport exit gate. Clearly, an understanding of visual perception is going to play a role in any answers, and more specifically, an understanding of visual attention...
FAQs
Fiber diameter and alignment affect how cells interact with a scaffold and how physical forces move through its structure. Alignment can provide directional organization, while diameter contributes to the architecture experienced by attached cells. Together, these features also influence fluid transport and the transmission of mechanical cues, making them important variables when designing biomaterials for specific biological responses.
Porosity determines the available spaces within and between fibers, which directly affects fluid transport through the network. It also contributes to the structural environment encountered by cells and can change how the network supports biological activity. Adjusting porosity therefore helps researchers balance transport-related performance with the architectural requirements of engineered tissues and other biomaterial systems.
Surface chemistry influences cell adhesion, whereas mechanical strength affects how a fiber network withstands and transmits physical forces. These properties act as distinct but complementary design variables: one helps regulate the interface between cells and material, and the other shapes the mechanical environment. Controlling both supports more deliberate tuning of proliferation and other biological responses.
Researchers tune fiber features by selecting suitable materials and controlling fabrication approaches such as electrospinning or controlled fiber assembly. They then characterize structural, physical, and chemical properties, including diameter, alignment, porosity, surface chemistry, and mechanical strength. This workflow connects fabrication choices with measurable scaffold behavior and helps determine whether the resulting material meets its intended design goals.
Fiber features are selected when a scaffold must reproduce important aspects of native extracellular matrix architecture while supporting a desired biological response. Researchers can adjust architecture, surface properties, and strength to influence cell adhesion, proliferation, fluid movement, and force transmission. This makes fiber-based design useful for tailoring scaffolds to the functional requirements of engineered tissue systems.
In wound dressings, fiber architecture and material properties can be tailored to influence fluid transport, cell interactions, and mechanical performance. In drug-delivery systems, the same design variables help establish a functional fiber network whose physical and chemical characteristics can be selected for the intended application. Characterizing these features helps relate biomaterial structure to performance across both uses.