Cancer Metabolism
Cancer Metabolism - Related Videos
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Cited by 5 •
2016
Integration of data from genome-wide sequencing experiments and metabolomics experiments is a challenge. In this paper we report, for the first time, generation, analysis and integration of transcriptome, cistrome and metabolome data from breast cancer cells treated with estradiol.
10:51
Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
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Cited by 31 •
2017
Here, a method is described for the preparation of 3-dimensional (3D) spheroid co-culture of pancreatic cancer cells and fibroblasts, followed by measurement of metabolic functions using an extracellular flux analyzer.
10:19
An Introduction to Cell Metabolism
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2023
In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction to cell metabolism briefly...
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
FAQs
The Warburg effect allows tumor cells to maintain heavy reliance on glycolysis and lactate production even when oxygen is available. This separates glucose breakdown from a simple response to oxygen shortage. In biological terms, the pattern helps explain how cancer cells can preserve an altered energy and biosynthetic program across changing conditions, including regions with limited oxygen.
Redirecting these nutrients supplies precursors for nucleotide, lipid, and protein synthesis. That allocation supports production of cellular building blocks needed for abnormal growth, rather than treating nutrient consumption as energy generation alone. The distinction matters because metabolic analysis must consider both fuel use and biosynthesis when explaining how tumors expand and maintain cellular components.
Low-oxygen environments are one setting in which altered metabolism can support survival. Cancer cells' use of glycolysis and nutrient-routing patterns helps them cope with restricted oxygen while continuing to obtain energy-related output and biosynthetic resources. Studying this relationship also connects tumor-cell metabolism with the surrounding tumor microenvironment, where oxygen availability is not uniform.
Metabolic biomarkers can capture altered nutrient use and other metabolic features of tumors. Their development helps researchers connect processes such as glycolysis, lactate production, and nutrient redirection with cancer-cell behavior. In biology, they are useful because they translate cellular metabolic changes into measurable signals that can support investigation of tumor growth, stress, and microenvironmental interactions.
Imaging strategies can help visualize or otherwise assess metabolic behavior in tumors, complementing molecular descriptions of glycolysis, lactate production, and nutrient use. Their relevance comes from connecting altered metabolism with conditions such as low oxygen and the tumor microenvironment. The overview identifies imaging as an application of this field but does not specify an imaging modality.
Targeting nutrient use or metabolic enzymes aims to interfere with the altered biochemical processes that support tumor growth and stress adaptation. This approach follows from the redirected use of glucose and glutamine and from glycolytic lactate production. In biology research, it provides a way to test whether disrupting metabolic support can weaken cancer-cell survival or expansion.