Device Fabrication
Device Fabrication - Related Videos
05:40
Fabricating Cotton Analytical Devices
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2016
To investigate simple fabrication approaches for multiple assay needs, we created a fluid-absorbing channel system made of cotton material. This device was used to establish a multiple detection platform, and solve contamination issues that commonly affect lateral flow-based biomedical devices, for clinical urinalysis of nitrite, total protein, and urobilinogen.
04:54
Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Cited by 30 •
2017
Solvent bonding is a simple and versatile method for fabricating thermoplastic microfluidic devices with high quality bonds. We describe a protocol to achieve strong, optically clear bonds in PMMA and COP microfluidic devices that preserve microfeature details, by a judicious combination of pressure, temperature, an appropriate solvent, and device geometry.
11:33
Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Cited by 12 •
2017
We detail a method to fabricate three-dimensional paper-based microfluidic devices for use in the development of immunoassays. Our approach to device assembly is a type of multilayer, additive manufacturing. We demonstrate a sandwich immunoassay to provide representative results for these types of paper-based devices.
11:06
Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices
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Cited by 4 •
2016
This protocol describes the synthesis and solution deposition of inorganic nanocrystals layer by layer to produce thin film electronics on non-conductive surfaces. Solvent-stabilized inks can produce complete photovoltaic devices on glass substrates via spin and spray coating following post-deposition ligand exchange and sintering.
14:48
PDMS Device Fabrication and Surface Modification
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Cited by 5 •
2007
FAQs
Patterning establishes the device’s intended geometry, often through photolithography, before later steps build and close that structure. Material deposition adds selected material, etching removes material to shape features, and bonding joins components. Packaging then prepares the completed structure for controlled biological interaction or measurement. The sequence links design dimensions to a usable platform.
Dimensions and surface conditions are functional variables, not merely manufacturing details. In a biological platform, they help determine how fluids are regulated, where biomolecules are presented, and how tissue-like environments are recreated. Controlling these properties supports consistent cell analysis and measurements because the device can impose defined physical and biological conditions rather than relying on an uncontrolled setting.
Silicon, polymers, metals, and glass are identified as material classes for constructing these devices. Selecting among them is part of converting a design into a physical platform, alongside patterning, deposition, etching, bonding, and packaging. In biological applications, the resulting construction must support the intended fluid regulation, biomolecule presentation, measurement, or tissue-environment recreation.
A practical workflow begins with a design and material selection, then uses patterning to establish structures. Deposition and etching modify those structures, bonding combines components, and packaging prepares the assembled device. Researchers must control dimensions and surface conditions throughout because the finished platform is intended to regulate fluids, present biomolecules, or recreate a tissue environment.
Researchers apply Device Fabrication when a biological experiment requires controlled fluid handling, defined biomolecule presentation, or a constructed tissue-like environment. The resulting microfluidic platforms, biosensors, and organ-on-chip devices support cell analysis, diagnostics, drug evaluation, and studies of biological function. The application depends on the biological interaction or measurement the device is designed to enable.
These platforms connect engineered physical conditions with biological readouts. Microfluidic devices support cell analysis, biosensors enable measurements, and organ-on-chip systems recreate tissue environments for examining biological function or evaluating drugs. In diagnostic settings, the fabricated structure provides a controlled setting for biological interactions that can be measured, helping researchers investigate cells and their behavior under defined conditions.
Organ-on-chip devices depend on fabricated structures to recreate tissue environments in a controlled format. Their dimensions, material construction, bonding, packaging, and surface conditions help establish the physical setting in which biological interactions can be studied. This makes them relevant to drug evaluation and investigations of biological function, complementing broader cell-analysis and diagnostic applications.