Mechanical Ventilation

Mechanical ventilation is the use of a machine to support or replace spontaneous breathing when the respiratory system cannot maintain adequate oxygen and carbon dioxide exchange. A ventilator delivers pressurized air, often enriched with oxygen, through an endotracheal tube or mask, while adjustable settings control breath volume or pressure, respiratory rate, and the timing of inspiration and expiration. In biology and clinical research, mechanical ventilation helps investigators examine lung mechanics, gas exchange, and injury responses, while clinicians use it to manage respiratory failure during critical illness, surgery, or recovery. Careful control of ventilation can sustain vital function while the underlying condition is treated.

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Education

JoVE Core - Medical-Surgical Nursing

Mechanical Ventilation II: Invasive Ventilation

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2025

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators. Negative-Pressure Ventilators Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...

Research

JoVE Journal - Medicine

A Structured Approach to Extubation in Mechanically Ventilated Rats

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2025

This study proposes a structured extubation approach tailored to rat models of mechanical ventilation (MV). The approach facilitates a smooth transition from MV to spontaneous breathing while minimizing extubation-related complications. Standardization of weaning, airway management, and post-extubation care enhances the reliability and reproducibility of experimental studies.

Mechanical Ventilation III: Noninvasive Ventilation

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2025

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy. Noninvasive Positive-Pressure Ventilation (NIPPV)

Mechanical Ventilation I: Indication and Settings

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2025

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...

Research

JoVE Journal - Medicine
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3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

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Cited by 1 •

2025

The proposed setup allows controlled mechanical ventilation and Magnetic Resonance imaging of 3D thorax movement in mice and rats. We have used this setup to study the pathophysiology underlying mechanical ventilation-induced respiratory muscle dysfunction.

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