Primary Olfactory Cortex

Primary olfactory cortex is a network of forebrain regions that receives the brain’s first cortical representation of smell, making it central to odor perception and the association of odors with behavior. It includes the piriform cortex and related areas, which receive distributed projections from olfactory bulb neurons through the lateral olfactory tract; this arrangement transforms receptor activity into odor representations and supports rapid integration with memory and emotion. In biology, studying the primary olfactory cortex helps explain how animals identify odors, regulate feeding and defensive responses, and form odor-linked memories. Its organization also provides a framework for investigating sensory coding, neural circuits, and dysfunction associated with impaired smell.

Primary Olfactory Cortex - Related Videos

Research

JoVE Journal - Behavior

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

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Cited by 21 •

2017

Using two different transcranial magnetic stimulation (TMS) protocols, this manuscript describes how to measure and compare cortical inhibition within the primary motor cortex when adopting different attentional foci.

Time-Lapse Imaging of Transfected Primary Mouse Cerebral Cortex Cells

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2025

Source: Landeira, B. S.,et al., Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System. J. Vis. Exp. (2017)The video demonstrates the use of time-lapse imaging to track fluorescently labeled cortical progenitors, monitor their division and differentiation, and study lineage development in primary cerebral cortex...

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

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2017

Olfactory sensory neurons express a wide variety of axon-sorting molecules to establish proper neural circuitry. This protocol describes an immunohistochemical staining method to visualize combinatorial expressions of axon-sorting molecules at the axon termini of olfactory sensory neurons.

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

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Cited by 2 •

2017

Live imaging is a powerful tool to study cellular behaviors in real time. Here, we describe a protocol for time-lapse video-microscopy of primary cerebral cortex cells that allows a detailed examination of the phases enacted during the lineage progression from primary neural stem cells to differentiated neurons and glia.

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice

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Cited by 13 •

2014

Cilia of olfactory sensory neurons contain proteins of the signal transduction cascade, but a detailed spatial analysis of their distribution is difficult in cryosections. We describe here an optimized approach for whole mount labeling and en face visualization of ciliary proteins.

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