Radiation Injury Model
Radiation Injury Model - Related Videos
08:17
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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Cited by 9 •
2015
Stereotactic ablative body radiation therapy (SBRT) involves the precise delivery of high-dose radiation to cancer tumor targets. A novel SBRT platform offers a first-of-its-kind gimbaled radiation accelerator mounted within a pivoting O-ring gantry capable of dynamic image-guided tumor tracking. Here, we describe dynamic tumor tracking for lung targets.
06:21
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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Cited by 13 •
2016
We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
02:59
Biological Effects of Radiation
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2020
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
FAQs
Two pathways contribute to injury. Radiation may ionize cellular molecules directly, or it may generate reactive oxygen species that damage biological components indirectly. Together, these routes can produce DNA strand breaks, while their combined effects help explain genomic instability, impaired repair, cell death, inflammation, and altered tissue regeneration. Comparing these outcomes links early molecular events with tissue-level dysfunction.
Dose-response relationships show how biological effects change as radiation exposure changes. In a model, researchers can track outcomes from DNA damage and impaired repair through cell death, inflammation, and altered regeneration. This progression helps distinguish molecular injury from later tissue dysfunction and provides a framework for comparing the severity of effects under controlled experimental exposure.
Impaired DNA repair can allow radiation-induced strand breaks to persist, while genomic instability indicates that cellular damage has produced continuing alterations. Measuring these outcomes helps researchers connect an initial exposure with later cell death or altered tissue regeneration. These endpoints are therefore useful for studying mechanism, rather than only the immediate appearance of injured cells.
These model types allow investigators to examine radiation effects at different biological levels. Cultured cells can reveal molecular and cellular injury, while organoids and laboratory animals extend analysis toward tissue dysfunction and altered regeneration. Comparing systems helps researchers connect early DNA damage and repair responses with later biological outcomes and choose a model suited to the question being studied.
Controlled irradiation conditions make exposure sufficiently defined for researchers to relate radiation input to biological outcomes. This is especially important when establishing dose-response relationships or evaluating a protective or therapeutic intervention. With a controlled exposure context, changes in DNA damage, cell death, inflammation, or regeneration can be interpreted more consistently across experimental comparisons.
Researchers can expose a model to radiation, measure injury-related outcomes, and determine whether an intervention changes those responses. Useful readouts include DNA strand breaks, genomic instability, impaired repair, cell death, inflammation, and altered tissue regeneration. This approach supports evaluation of strategies intended to reduce biological damage or improve recovery after radiation exposure.
In biology, these models help connect radiation exposure with mechanisms of injury and tissue dysfunction. Their applications include studying risks associated with cancer treatment, environmental radiation exposure, and spaceflight. By examining effects from molecular damage through altered regeneration, they also provide a basis for comparing biological responses and assessing interventions across these settings.