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Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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Medicine
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JoVE Journal Medicine
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

DOI:
10.3791/53573-v

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06:21 min

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May 27, 2016

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, , , , , ,
1Department of Radiation Oncology,University of Toronto, 2Department of Physics,Ryerson University, 3Department of Medical Biophysics,University of Toronto, 4Ontario Cancer Institute / Campbell Family Institute for Cancer Research

Chapters

  • 00:05Title
  • 00:46Diffuse Optical Spectroscopy (DOS) Data Acquisition: Preparations
  • 01:55Taking DOS Measurements from an Anesthetized Mouse
  • 03:01Mouse Irradiation
  • 04:32Results: DOS and Traditional Measurements
  • 05:36Conclusion

Summary

Automatic Translation

Automatic Translation

We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.

Tags

Keywords: Diffuse Optical SpectroscopyAcute Ionizing RadiationSkin ToxicityMouse ModelBiomarkerRadiation TherapyRadiation Skin ToxicityReflectanceAnesthesiaMouse Irradiation

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