Silicon Nitride Probes
Silicon Nitride Probes - Related Videos
09:46
Fabrication and Characterization of High-Q Silicon Nitride Membrane Resonators
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Cited by 1 •
2025
This article traces the life cycle of a silicon nitride membrane resonator, from design through fabrication to characterization.
17:37
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
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We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.
05:45
Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
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Cited by 24 •
2011
Extracellular recordings of neuronal activity using silicon probes in the anesthetized rat will be described. This technique allows information to be obtained across multiple brain areas from more than 100 neurons simultaneously. It provides information with single cell resolution about neuronal ensembles dynamics in multiple local circuits.
07:03
Low-energy Cathodoluminescence for (Oxy)Nitride Phosphors
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Cited by 2 •
2016
An excellent chemical and luminescence stabilities of (oxy)nitride phosphors present it as an promising alternative to currently used sulfide and oxide phosphors. In this paper, we present the way to investigate its local luminescence properties using low-energy cathodoluminescence (CL).
05:02
Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
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Cited by 5 •
2019
This study presents a feasible procedure for synthesizing gold dendritic nanoforests on titanium nitride/silicon substrates. The thickness of gold dendritic nanoforests increases linearly within 15 min of a synthesis reaction.
FAQs
A low spring constant allows the cantilever to respond to small tip-sample forces without requiring large interactions. This sensitivity is important for soft biological materials, where excessive force could obscure nanoscale features or alter the sample. In practice, mechanically stable probes with low spring constants support measurements of membranes, proteins, cells, and other delicate structures.
As the probe scans a specimen, interactions between its tip and the sample bend the cantilever. A laser beam detects that deflection, providing a signal that can be converted into information about surface topography or mechanical behavior. The same basic detection principle therefore supports both structural imaging and measurements of forces acting at biological interfaces.
Imaging uses changes in cantilever deflection during scanning to describe nanoscale surface features. Force spectroscopy instead uses tip-sample interactions to quantify properties such as adhesion, elasticity, and molecular interactions. These complementary measurements allow one probe platform to provide spatial information about a biological sample and quantitative information about how its components respond to contact or separation.
Their mechanical stability and compatibility with aqueous environments allow measurements under conditions closer to those experienced by biological materials. This is valuable because cells, membranes, proteins, and other soft samples can be examined without restricting the analysis to a dry setting. The resulting measurements can better reflect biological structure and mechanical behavior in relevant surroundings.
A typical workflow places the biological specimen within the scanning setup, brings the sharp probe tip into interaction with its surface, and scans the specimen while monitoring cantilever bending. Laser-based detection records the deflection signal, which is then interpreted as topographic or mechanical information. Researchers can select imaging or force spectroscopy depending on the desired outcome.
Force spectroscopy is appropriate when the goal extends beyond mapping surface features to quantifying interactions or mechanical properties. It can measure adhesion, elasticity, and molecular interactions, as well as changes associated with disease or cellular responses. This makes the approach useful for studying how biological samples differ in physical behavior, not only how their surfaces are arranged.
The probes can be used with cells, membranes, proteins, and other soft biological materials. Atomic force microscopy provides nanoscale surface or mechanical information from these samples, while aqueous compatibility supports measurements under near-physiological conditions. Consequently, the technique connects nanoscale physical observations with biological questions involving structure, material properties, and cellular state.
Force measurements can reveal changes in adhesion, elasticity, or molecular interactions that accompany disease or cellular responses. By comparing these properties across biological samples, researchers can investigate physical alterations that may not be apparent from surface topography alone. The approach therefore adds a quantitative mechanical perspective to studies of cell behavior and disease-associated changes.