Folic Acid Nanoparticles
Folic Acid Nanoparticles - Related Videos
02:53
Functionalized Nanoparticle Targeting of Ovarian Cancer: A Technique to Facilitate Folic Acid-conjugated Nanoparticle Contrast Agent Uptake by Ovarian Cancer Cells
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2023
In this video, we demonstrate a technique to facilitate the internalization of folic acid-capped copper sulfide nanoparticles (CuS NPs). Folic acid-functionalized CuS NPs have the ability to target folate-receptors which are overexpressed in many ovarian cancer cells.
09:43
Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
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Cited by 11 •
2013
Silica nanoparticles were prepared using acid-catalysis of a siloxane precursor and microwave-assisted synthetic techniques resulting in the controlled growth of nanomaterials ranging from 30-250 nm in diameter. The growth dynamics can be controlled by varying the initial silicic acid concentration, time of the reaction, and temperature of reaction.
09:02
Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
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Cited by 1 •
2015
We report protocols for “polymerizing” various types of polymer-encapsulated metal nanoparticles into long chains of “homo-“ and “co-polymers”.
03:19
Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
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2024
This protocol describes the method for reducing dietary intake of folic acid or choline in female mice prior to pregnancy with the objective of investigating the impact of maternal diet on offspring health outcomes.
09:23
Harmonic Nanoparticles for Regenerative Research
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Cited by 1 •
2014
Protocol details are provided for in vitro labeling human embryonic stem cells with second harmonic generating nanoparticles. Methodologies for hESC investigation by multi-photon microscopy and their differentiation into cardiac clusters are also presented.
FAQs
Folate-receptor binding does more than provide surface recognition: it can trigger receptor-mediated endocytosis, a cellular uptake route that draws the nanoparticle into the cell. Once internalized, the particle can release its cargo intracellularly. This mechanism is central to studying whether targeted delivery improves access to cancer cells compared with broader cellular exposure.
Particle composition, size, surface chemistry, and folate density can all influence performance. These properties determine how the system presents folic acid and interacts with cells, while the target tumor’s receptor profile affects whether binding and uptake are likely. Consequently, changing formulation parameters may alter cellular uptake and cargo-delivery behavior.
Folate density is most informative when considered alongside the receptor profile of the target cells. A surface carrying folic acid can support receptor-directed uptake only when relevant cells express folate receptors. In cancer studies, evaluating both variables helps researchers interpret differences in nanoparticle entry among tumor models and assess whether targeting is plausible.
The same receptor-directed strategy can be investigated with different payloads, including chemotherapeutic agents, nucleic acids, and imaging probes. Chemotherapy studies focus on intracellular drug delivery, nucleic-acid studies examine delivery of genetic materials, and imaging applications use diagnostic cargo. This flexibility allows one platform concept to address treatment and tumor-investigation objectives.
A study should relate nanoparticle composition, size, surface chemistry, and folate density to the receptor characteristics of the intended tumor model. Researchers can then examine whether those design choices support cellular uptake and intracellular cargo release. Considering formulation and biological context together is important because performance depends on both particle properties and target-cell features.
Key outcomes include evidence of cellular uptake, intracellular release of therapeutic or diagnostic cargo, and the possibility of reducing exposure to healthy tissue. Interpretation depends on the target tumor’s folate-receptor profile and the nanoparticle’s formulation properties. These systems therefore help researchers connect delivery behavior with potential therapeutic or imaging value.