Intra-uterine Injection

Intra-uterine injection is a technique that delivers cells, drugs, or other experimental materials directly into the uterine cavity, enabling localized investigation of uterine biology and disease. The procedure introduces a measured suspension through the cervix or uterine wall, where the material contacts the endometrial lining and can initiate localized responses or tumor formation under controlled conditions. In cancer research, this approach helps generate and study uterine tumor models, evaluate cancer cell behavior, and test targeted therapies while limiting exposure to other tissues. It can also support investigations of tumor development, treatment response, and mechanisms underlying endometrial cancer.

Intra-uterine Injection - Related Videos

Research

JoVE Journal - Medicine

Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo

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Cited by 16 •

2015

This manuscript provides a protocol for implanting telemeters in the mouse for the purpose of measuring intrauterine pressures during pregnancy.

Research

JoVE Journal - Medicine
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Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

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Cited by 1 •

2025

Intrauterine adhesions (IUAs), the most common pathological consequence of endometrial injury, severely impair reproductive function. Trauma and infection are widely recognized as key risk factors for IUA development. We have successfully established a reproducible rat model of IUAs by combining two critical injury methods: mechanical curettage and infectious induction with lipopolysaccharide.

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Intrauterine Drug Delivery Systems

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2026

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

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Cited by 11 •

2013

We describe examination of fetal cardiac function with contemporary functional fetal echocardiography and fetoplacental Doppler ultrasound using the VisualSonics VEVO 2100 microultrasound in a surgically induced model of intrauterine fetal growth restriction in a rabbit.

In Utero Intraventricular Injection and Electroporation of E15 Mouse Embryos

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Cited by 53 •

2007

In-utero in-vivo injection and electroporation of the embryonic mouse neocortex provides a powerful tool for the manipulation of individual progenitors ...

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