Liver Function Tests
Liver Function Tests - Related Videos
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Cited by 29 •
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We describe a method of ex vivo machine perfusion of human liver grafts at subnormothermic temperature (21 °C).
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05:21
Computerized Adaptive Testing System of Functional Assessment of Stroke
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Cited by 2 •
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12:35
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
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Cited by 14 •
2011
The study of liver sinusoidal endothelial cells (SECs) must be performed with primary cells obtained from the animal as no cell lines exist. This method relies on liver digestion and differential centrifugation for SEC purification for subsequent culturing and experimentation.
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
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Cited by 21 •
2015
Here we present a protocol describing oxygenated ex situ machine perfusion of donor liver grafts. This article contains a step by step protocol to procure and prepare the liver graft for machine perfusion, prepare the perfusion fluid, prime the perfusion machine and perform oxygenated normothermic machine perfusion of the liver graft.
FAQs
Liver function tests are interpreted as a pattern rather than as isolated numbers. Relative abnormalities across aminotransferases, alkaline phosphatase, and bilirubin can support recognition of hepatocellular injury or disturbed bile flow, while albumin and prothrombin time provide information about synthetic capacity. This combined reading helps clinicians characterize the dominant hepatic process more effectively than any single result.
Different markers answer different clinical questions. Alanine aminotransferase and aspartate aminotransferase contribute to assessment of liver injury; alkaline phosphatase and bilirubin help evaluate bile flow; albumin and prothrombin time inform protein synthesis and synthetic function. Because these measurements represent different processes, a panel can reveal a more nuanced pattern than one biomarker alone.
An abnormal result does not automatically establish a liver disorder. Nonhepatic conditions and medication effects can also produce abnormal values, so clinicians must interpret results alongside the clinical context. This safeguards against treating a laboratory signal as a diagnosis and emphasizes why the overall pattern and circumstances matter when evaluating suspected hepatic disease.
Albumin and prothrombin time extend assessment beyond cellular injury by indicating the liver’s capacity to synthesize essential proteins. Their inclusion helps distinguish evidence of injury from evidence that functional capacity may be impaired. This distinction is clinically important because characterization of disease and assessment of prognosis require more than identifying abnormalities in injury-related biomarkers.
The evaluation begins with a blood sample, from which laboratories quantify selected biomarkers. The panel may include alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time. Clinicians then review the measurements together, using the resulting pattern to support assessment of injury, bile flow, and synthetic function.
They support several stages of clinical care: initial identification and characterization of hepatic abnormalities, monitoring of disease over time, assessment of treatment, and evaluation of prognosis. Their value therefore extends beyond detecting an abnormality. Results interpreted over time and in context can help clinicians judge how a condition or its management is evolving, although clinical interpretation remains essential.