Femtosecond Laser Ablation
Femtosecond Laser Ablation - Related Videos
13:02
Fabrication of 1-D Photonic Crystal Cavity on a Nanofiber Using Femtosecond Laser-induced Ablation
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Cited by 3 •
2017
We present a protocol for fabricating 1-D photonic crystal cavities on subwavelength diameter silica fibers (optical nanofibers) using femtosecond laser-induced ablation.
07:27
Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
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Cited by 43 •
2011
Acute kidney injury (AKI) in humans is a common clinical problem caused by damage to the epithelial cells that comprise kidney nephrons, and AKI is associated with high mortality rates of 50-70%1. Following epithelial cell destruction, nephrons have a limited ability to regenerate, though the mechanisms and limitations that guide this phenomenon remain poorly understood. In this video article, we describe our technique for targeted laser ablation of kidney nephron cells in the zebrafish...
05:13
Selective Single-Neuron Laser Ablation in a Zebrafish Larva Using a Confocal Microscope
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2025
Source: Morsch, M., et. al., Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy. J. Vis. Exp. (2017) In this video, we explore the technique of high-intensity UV laser ablation for precisely targeting and studying individual neurons in transgenic zebrafish. We demonstrate how to prepare, immobilize, and visualize neuronal responses, highlighting the cellular dynamics of injury and recovery.
02:39
Monitoring Recovery of Laser-Ablated Interneuromast Cells in Zebrafish Using Confocal Microscopy
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2025
Source: Volpe, B. A., et al. Confocal Microscope-Based Laser Ablation and Regeneration Assay in Zebrafish Interneuromast Cells. J. Vis. Exp. (2020) This video demonstrates monitoring interneuromast cell recovery in zebrafish using confocal microscopy, tracking cell death and repair through time-lapse fluorescence imaging.
01:20
Laser Interstitial Thermal Therapy for Intracranial Tumor Ablation in a Human Patient
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2025
Begin with an anesthetized human patient with an exposed skull. The patient is diagnosed with an intracranial tumor.Drill into the exposed skull to create a hole, generating an access point.Using stereotactic guidance, insert a laser diffusing fiber or LDF along the predetermined path and secure it in place.Transfer the patient to an MRI scanner and connect the LDF to a laser source.Capture MRI images from multiple angles to visualize the fiber path and the tumor.This confirms the LDF’s...
FAQs
The pulse delivers energy before significant heat diffusion can occur. At the surface, this intense interaction drives multiphoton ionization, in which several photons contribute to ionizing material, followed by rapid plasma formation. The resulting plasma ejects material from the surface, allowing removal to occur without relying primarily on prolonged heating.
A heat-affected zone remains small because the pulse ends before deposited energy can spread substantially into surrounding material. Material near the interaction site is removed through rapid plasma formation, while neighboring regions receive less thermal exposure. This behavior supports clean processing and helps preserve nearby features during precision engineering operations.
Multiphoton ionization provides a pathway for the intense optical pulse to initiate plasma formation at the material surface. Because the process begins through rapid energy absorption rather than extended heating, it supports localized material ejection. This mechanism is important when engineering designs require high-resolution structures and limited thermal damage.
The technique applies across metals, semiconductors, ceramics, polymers, and transparent materials. This broad material range makes it useful for engineering tasks that combine different material properties, such as miniature electronic structures, optical components, and microfluidic devices. The same ultrashort-pulse principle can therefore support precision machining across varied manufacturing platforms.
Engineering applications include microfluidic channels, surgical components, optical components, surface textures, and miniature electronic structures. These examples reflect the method’s ability to remove material with fine spatial control while limiting thermal effects. It is consequently relevant to devices and surfaces where small features, clean processing, and dimensional accuracy influence performance.
The process is valuable when manufacturing requires tight dimensional control together with minimal thermal damage. Its application to metals, semiconductors, ceramics, polymers, and transparent materials broadens its usefulness across advanced fabrication. Engineers can apply it to produce small-scale functional features, including channels, textures, optical parts, and electronic structures, where clean results are essential.