Structural Flexibility
Structural Flexibility - Related Videos
08:49
Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
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Cited by 1 •
2025
Computational methods hold promises for expediting drug discovery, yet they frequently overlook the dynamic nature of protein structures. Here, we discuss ensemble-based docking analysis to indirectly incorporate protein flexibility, potentially improving the accuracy and reliability of drug discovery efforts.
08:30
Operant Procedures for Assessing Behavioral Flexibility in Rats
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Cited by 69 •
2015
The ability to assess executive functions such as behavioral flexibility in rats is useful for investigating the neurobiology of cognition in both intact animals and disease models. Here we describe automated tasks for assessing strategy shifting and reversal learning, which are particularly sensitive to disruptions in prefrontal cortical networks.
12:03
Dynamics of Structures
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2023
Source: Roberto Leon, Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA It is rare nowadays that a whole year goes by without a major earthquake event wreaking havoc somewhere around the world. In some cases, like the 2005 Banda Ache earthquake in Indonesia, the damage involved large geographic areas and casualties in the six figures. In general, the number and intensity of earthquakes is not increasing, however, the vulnerability of the built environment is...
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
06:40
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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Cited by 99 •
2013
Insertion of flexible neural microelectrode probes is enabled by attaching probes to rigid stiffeners with polyethylene glycol (PEG). A unique assembly process ensures uniform and repeatable attachment. After insertion into tissue, the PEG dissolves and the stiffener is extracted. An in vitro test method evaluates the technique in agarose gel.
FAQs
Material properties determine how readily a structure changes shape, while geometry influences how that response develops throughout the system. Together with boundary conditions and connections, they establish stiffness and affect load distribution. Engineers therefore examine these features as a combination, since changing one can alter deflection and the way forces move through the structure.
Structural flexibility and stiffness describe closely related aspects of a structure’s response. A change in stiffness affects how loads are distributed and how much deflection occurs, while flexibility also influences vibration behavior. Evaluating both helps engineers understand whether a design will maintain its intended performance under applied loads, environmental forces, or controlled actuation.
Boundary conditions and connections determine how a structure is restrained and how its parts interact. These features can change load distribution, stiffness, and the resulting deformation or vibration even when the material and overall geometry remain unchanged. Including them in analysis produces a more representative assessment of structural response and potential performance limitations.
Engineers manage flexibility because excessive deformation, vibration, fatigue, or instability can reduce safety and function, while some compliance may be necessary for effective operation. The design objective is therefore not maximum rigidity in every case. It is to control structural response so the system preserves useful movement or adaptability without unacceptable performance loss.
An evaluation should consider the applied loads, environmental forces, and any controlled actuation, then relate those conditions to material properties, geometry, boundary conditions, and connections. Engineers use these factors to judge stiffness, load distribution, deflection, and vibration. The resulting assessment supports decisions about whether the structure meets its intended performance requirements.
Structural flexibility is especially relevant in bridges, aircraft, robotic mechanisms, and deployable structures, where deformation and vibration can affect operation or performance. In these systems, engineers analyze the response to external forces or controlled movement and use the findings to support safer designs, improved dynamic performance, and efficient use of materials.