Analgesic Regimen

An analgesic regimen is a planned approach to preventing or relieving pain through the selection, timing, dosing, and adjustment of one or more pain-relieving treatments. It works by targeting pain pathways at different stages, including the generation of inflammatory signals, transmission through peripheral nerves and the spinal cord, and perception in the brain; multimodal regimens may combine therapies with complementary mechanisms. In medicine, clinicians tailor regimens to pain severity, cause, duration, patient characteristics, and treatment risks. Appropriate planning can improve comfort and function while limiting adverse effects, medication interactions, tolerance, and other complications during acute or chronic pain management.

Analgesic Regimen - Related Videos

Research

JoVE Journal - Medicine

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Cited by 26 •

2013

Psoriasis is a chronic, immune-mediated inflammatory skin disease. The Goeckerman regimen, formulated for the treatment of psoriasis, consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT). The following protocol is for the administration of Goeckerman therapy for the treatment of moderate-to-severe psoriasis.

Synergistic Effect of Intracranial and Intraperitoneal Delivery of Analgesic Drugs on Thermal Pain Response in a Rat

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2025

Source: Martinez, E., et al. Intracranial Pharmacotherapy and Pain Assays in Rodents. J. Vis. Exp. (2019).This video demonstrates the intracranial administration of an analgesic drug in an anesthetized rat with a pre-implanted guide cannula in the prefrontal cortex. An additional analgesic drug is co-administered intraperitoneally. Following recovery, the rat’s thermal pain response is assessed using Hargreave’s apparatus, where paw withdrawal latency is measured to evaluate the analgesic...

Research

JoVE Journal - Neuroscience
Free Sample

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Cited by 41 •

2014

We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Dosage Regimen: Individualization

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2025

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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2024

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

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