Cornea Excision

Cornea excision is a surgical procedure that removes part or all of the cornea, the transparent outer layer at the front of the eye, to treat disease, injury, or abnormal tissue. Surgeons carefully separate and cut the affected corneal tissue, often using a trephine or microsurgical blade, while preserving the eye’s structural integrity and, when necessary, preparing the site for grafting. In medicine, cornea excision supports corneal transplantation, removal of scarred or opaque tissue, treatment of selected tumors, and diagnostic biopsy. Its success depends on precise tissue removal, infection control, and restoration of the cornea’s optical clarity and protective function.

Cornea Excision - Related Videos

Research

JoVE Journal - Medicine

A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe

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Cited by 7 •

2012

The paper describes a simplified technique to excise corneal and to eviscerate retinal tissues from the ocular globe of human cadaveric donors. The technique described here will help to excise good quality tissues to be used for transplantation, surgical or research purposes without damaging other tissues of the ocular globe.

Education

JoVE Core - Molecular Biology
Free Sample

Base Excision Repair

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2020

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...

A Mouse Model of the Cornea Pocket Assay for Angiogenesis Study

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Cited by 20 •

2011

The cornea is unique in that it lacks vascular tissues. However, robust blood vessel growth and survival can be induced in the cornea by potent angiogenic factors. Therefore, the cornea can provide with us a valuable tool for angiogenic studies. This protocol demonstrates how to perform the mouse model of cornea pocket assay and how to assess the angiogenesis induced by angiogenic factors using this model.

Anterior Eye Segment Dissection: A Method to Isolate Cornea Bearing Anterior Segment from Porcine Eye

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2025

In this video, we demonstrate the dissection of the cornea-bearing anterior segment of the porcine eye. The isolated segment can be used for organ culturing to study the pathophysiology of eye disorders.

Assessment of Cornea and Tear Smoothness in an Autoimmune Dry Eye Rat Model

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2025

This video demonstrates a method for assessing corneal smoothness and tear film stability in an autoimmune rat model. It highlights the impact of gland dysfunction on tear film stability, crucial for understanding dry eye disease.

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