Endometriosis Mouse Model
Endometriosis Mouse Model - Related Videos
08:02
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
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Cited by 62 •
2012
A description of the surgical induction of endometriosis in mice and rats by auto-transplantation of uterine tissue to the arterial cascade of the intestinal mesentery.
08:16
Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
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Cited by 10 •
2019
Here, we present a protocol for live-imaging of fluorescently labeled human endometrial fragments grafted in mice. The method allows studying the effects of drugs of choice on endometriotic lesion size through monitoring and quantification of fluorescence emitted by the fluorescent reporter on real...
07:20
Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
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Cited by 21 •
2012
Loss of peritoneal integrity provides a new paradigm to understand and treat chronic pelvic pain in women with mild forms of endometriosis and can be easily detected using intraoperative instillation of dye at the time of laparoscopy.
07:12
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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Cited by 2 •
2020
Many rodent models of endometriosis are limited by technical complexity, reproducibility, and/or need for immunocompromised animals or special reporter mice. We present a simplified system of lesion induction using any experimental mouse with an independently verifiable, objective scoring system and with no requirement for ovariectomy or survival surgery.
06:24
Mouse Models of Periventricular Leukomalacia
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Cited by 28 •
2010
We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
FAQs
After researchers introduce endometrial tissue or cells into female mice, the material can establish lesions outside the uterus. These lesions provide a localized setting in which researchers can examine how abnormal tissue persists, interacts with surrounding structures, and contributes to disease-associated changes. The model therefore connects lesion formation with downstream inflammatory, immune, vascular, and pain-related responses.
These processes represent distinct biological responses associated with lesion development. Inflammation reflects local tissue activation, immune responses show how surrounding defenses react, and angiogenesis refers to the formation of blood vessels that may accompany lesion growth. Measuring them separately helps researchers determine which mechanisms are altered and whether a candidate intervention affects one or several disease-related pathways.
Pain-related changes provide a functional outcome alongside cellular and tissue findings. A study can therefore evaluate whether lesion-associated inflammation and interactions with surrounding tissues correspond to altered pain responses in the mice. Including this outcome makes the model more relevant to endometriosis research because it links biological mechanisms with a symptom-related measure rather than examining lesions alone.
The model places introduced endometrial material within a living biological environment, allowing researchers to examine responses from both the lesion and adjacent tissues. This setting supports investigation of local inflammation, immune activity, angiogenesis, and pain-related changes together. Such observations can clarify how ectopic lesions influence their surroundings and how surrounding tissues may contribute to disease progression.
A typical study begins by introducing endometrial tissue or cells into female mice. Researchers then monitor the resulting ectopic lesions and assess selected outcomes, such as inflammatory activity, immune responses, angiogenesis, or pain-related changes. The experimental design can subsequently compare these measurements across treatment conditions, providing a controlled way to investigate mechanisms or therapeutic effects.
Researchers may choose it when they need a controlled system for linking disease mechanisms with measurable outcomes. It supports studies of how lesions develop, how they interact with surrounding tissues, and how biological responses change during disease progression. The model is also useful for preclinical evaluation of potential hormonal, anti-inflammatory, or surgical treatments before further therapeutic development.
The model can support preclinical testing of hormonal treatments, anti-inflammatory approaches, and surgical interventions. Researchers can examine whether an intervention changes lesion-associated inflammation, immune responses, angiogenesis, pain-related outcomes, or other measurable features. Comparing these outcomes helps characterize a treatment's potential effects and indicates which disease mechanisms may be influenced.
Its medical value comes from integrating several levels of investigation within one controlled system. Researchers can connect ectopic lesion formation with local tissue interactions, inflammatory and immune responses, angiogenesis, and pain-related changes, then relate those findings to treatment effects. This combination supports mechanistic research and helps guide the development of more effective endometriosis therapies.