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Chapters
- 00:00Title
- 00:35Introduction
- 01:52Creating Neonatal Brain Injury in P6 Mice
- 03:33Results of Mouse Models of Preiventricular Leukomalacia
- 05:40Conclusion
We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
Tags
Mouse ModelsPeriventricular LeukomalaciaPVLBrain InjuryPremature InfantsCerebral PalsyWhite Matter DamageOligodendroglial InjuryHypoxia/ischemiaSystemic Infection/inflammationP6 MiceNeonatal Brain InjuryCarotid LigationEndotoxin Lipopolysaccharide (LPS)Myelin Basic Protein (MBP)O1Electron Microscopic ExaminationHippocampusThalamusDisease PathogenesisTransgenic Mouse StrainsDrug TrialsTherapeutic AgentsStem Cell TransplantationImmunodeficiency Mouse Strains
