Multi-organ Dysfunction
Multi-organ Dysfunction - Related Videos
10:05
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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Cited by 91 •
2015
Here, we present a protocol to coculture primary cells, tissue models and punch biopsies in a microfluidic multi-organ chip for up to 28 days. Human dermal microvascular endothelial cells, liver aggregates and skin biopsies were successfully combined in a common media circulation.
04:48
Swin-PSAxialNet: An Efficient Multi-Organ Segmentation Technique
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2024
The present protocol describes an efficient multi-organ segmentation method called Swin-PSAxialNet, which has achieved excellent accuracy compared to previous segmentation methods. The key steps of this procedure include dataset collection, environment configuration, data preprocessing, model training and comparison, and ablation experiments.
07:35
The Multi-group Experiment
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2023
Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University A multi-group design is an experimental design that has 3 or more conditions/groups of the same independent variable. This video demonstrates a multi-group experiment that examines how different interethnic ideologies (multiculturalism and color-blind) influence feelings about diversity and actions toward and out-group member. In providing an overview of how a researcher conducts a multi-group...
08:24
Multi-Photon Laser Ablation of Cytoplasmic Microtubule Organizing Centers in Mouse Oocytes
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Cited by 2 •
2022
An optimized protocol is presented that enables the depletion of cytoplasmic microtubule organizing centers in mouse oocytes during metaphase I using a near-infrared femtosecond laser.
03:02
Organic Compounds
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2020
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
FAQs
The central mechanism is a maladaptive inflammatory response that extends beyond the initial injury. It can damage the endothelium, the cell layer lining blood vessels, while disrupting microcirculation. These changes impair tissue perfusion and limit the delivery and use of oxygen at the cellular level, allowing dysfunction to progress across organ systems rather than remaining confined to the original site.
Organ performance depends not only on blood flow but also on effective oxygen use by cells. In multi-organ dysfunction, inadequate cellular oxygen use can compound reduced tissue perfusion caused by endothelial injury and microcirculatory disturbance. This combined impairment helps explain why several organs may deteriorate during severe systemic illness and why clinicians monitor for progressive changes.
Infection, trauma, shock, and other major insults can initiate the systemic processes associated with multi-organ dysfunction. The initiating event is important because it directs attention toward treating the underlying cause, while the resulting inflammatory, vascular, and cellular disturbances help determine how widely organ performance is affected. Recognizing both aspects supports more focused clinical assessment.
Endothelial injury disrupts the normal function of small blood vessels, while impaired microcirculation reduces effective tissue perfusion. Together, these changes can limit oxygen availability to tissues and promote declining organ performance. Their importance extends beyond a single organ because vascular and perfusion abnormalities can affect multiple systems, contributing to progressive rather than isolated dysfunction.
Recognition focuses on identifying progressive loss of function across two or more organ systems in a patient with severe systemic illness. Clinicians use early risk assessment and close monitoring to detect worsening performance and complications. This approach is important because timely recognition can guide treatment of the underlying cause and the initiation or adjustment of organ-supportive care.
Management prioritizes treatment of the underlying cause while providing organ-supportive care for the affected systems. Close monitoring helps clinicians assess progression and respond to complications as they emerge. The overall goal is to limit secondary injury, maintain organ function as much as possible, and address the systemic illness rather than focusing only on one failing organ.
Research informs critical-care protocols, biomarker development, and strategies designed to prevent secondary injury. Biomarkers may support risk assessment, while protocols help organize monitoring and supportive treatment in severe systemic illness. Together, these research directions aim to improve recognition, guide clinical decisions, and ultimately strengthen patient outcomes in settings where multiple organ systems are threatened.