Organ Dysfunction
Organ Dysfunction - Related Videos
03:02
Organic Compounds
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2020
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
09:39
Mapping Dysfunctional Protein-Protein Interactions in Disease
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2025
Here, we present a protocol to enable the capture and identification of disease-specific protein-protein interactions from native cells and tissues using chemical probes and mass spectrometry. The resulting interaction datasets are analyzed through a dedicated web-based platform to reveal dynamic network dysfunctions and pathway alterations linked to disease.
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Cited by 1 •
2025
Mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD) with metabolic dysfunction, hepatic gene expression changes, and liver histopathological alterations that resemble human MASLD, including fibrosis that progresses to advanced fibrosis stage 3. This model can be used in studies of MASLD pathophysiology and in pre-clinical studies of new therapies.
06:06
Genetics of Organisms - Concepts
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2019
Mendelian Genetics Evolution is caused by changes in the genetic composition of populations. In the field of population genetics, scientists model this process as changes in the frequency of alleles at individual genetic loci. This simple representation of how evolution occurs dates to Gregor Mendel’s analysis of trait inheritance patterns in pea plants, first presented in 1865. Mendel determined, using rigorous collection of data, that noticeable traits are controlled by two alleles of each...
08:45
Whole Organ Tissue Culture
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2023
Whole organs can be cultured ex vivo using specialized bioreactors with the goal of repairing or replacing entire organs. This method uses a donor organ that is stripped of all cells, leaving behind the three-dimensional structure, which is then repopulated with new cells. This video demonstrates the whole organ culture of lungs and shows how a dynamic culture that mimics the mechanical stimulation in the body is needed to induce native tissue properties.
FAQs
Organ dysfunction can arise when several linked physiological processes fail at once. Reduced blood flow limits oxygen delivery, while inflammation, infection, toxins, or cellular injury can interfere with filtration, secretion, and energy production. These mechanisms help clinicians connect an observed functional decline with a likely source of injury and determine urgency.
A local disturbance may become systemic when it disrupts processes that other organs depend on, particularly circulation, oxygen delivery, or metabolic balance. Progression can occur from single-organ involvement to multiple-organ failure, so clinicians must watch for changing patterns rather than interpreting each organ in isolation.
Clinical assessment, laboratory biomarkers, and imaging provide complementary evidence rather than a single universal measure. Assessment shows how physiology is changing, biomarkers can indicate altered function or injury, and imaging can reveal relevant structural or functional patterns. Together, these findings support diagnosis and risk assessment and help guide decisions about treatment intensity.
A practical evaluation begins by recognizing a concerning clinical pattern, then combining bedside assessment with laboratory biomarkers and imaging. Clinicians use these findings to assess the extent of dysfunction, consider whether one or several organs are involved, and identify the underlying problem. This integrated process supports timely treatment.
Management depends on the mechanism and severity rather than on a single intervention. Medical care may restore perfusion, treat the underlying cause, or provide organ support while recovery is assessed. When function cannot be adequately maintained, transplantation may be considered. These options connect physiologic findings with immediate stabilization and longer-term care.
In critical care, organ dysfunction helps clinicians organize diagnosis, risk assessment, and support when illness affects vital physiological processes. The same framework also applies to chronic disease management, where ongoing decline may require continued assessment and treatment. Its clinical value lies in linking measurable changes in organ performance to risk assessment and care planning.