Orthotopic Position
Orthotopic Position - Related Videos
03:02
Orthotopic Inoculation of Thyroid Cancer Cells into Murine Thyroid: A Procedure to Establish Orthotopic Thyroid Cancer Mouse Model
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2023
This video describes the procedure for orthotopic inoculation of thyroid cancer cells into the thyroid gland of mouse models, which may then serve as a valuable platform to assess carcinogenesis and discover potential treatment strategies.
08:43
Orthotopic Mouse Model of Colorectal Cancer
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Cited by 109 •
2007
Two techniques can be used to establish this model: injection of a cancer cell suspension into the cecal wall or transplantation of a piece of subcutaneous tumor onto the cecum. This model is useful for studying the natural progression of colorectal cancer and testing new therapeutic agents against colorectal cancer.
09:16
Orthotopic Small Bowel Transplantation in Rats
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Cited by 4 •
2012
Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.
18:25
Orthotopic Liver Transplantation in Rats
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Cited by 31 •
2012
We present an easy-to-establish revision of the classical two-cuff technique for orthotopic liver transplantation in rat.
07:15
Orthotopic Hind Limb Transplantation in the Mouse
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Cited by 24 •
2016
This novel model for orthotopic hind limb transplantation in the mouse, applying a non-suture cuff technique for super-microvascular anastomosis, provides a powerful tool for in vivo mechanistic immunological research related to vascularized composite allotransplantation (VCA).
FAQs
Anatomical placement influences function by restoring the structure to the environment normally associated with it. In that setting, nearby tissues can provide the expected spatial relationships, local blood supply, tissue architecture, and anatomical connections. These factors may support integration and help the implanted or transplanted structure interact with surrounding tissues in a clinically relevant way.
Compared with ectopic or heterotopic placement, orthotopic placement is intended to preserve the anatomical context of the native structure. The comparison matters because changing location can alter the surrounding tissue relationships that guide function and integration. Thus, placement strategy becomes an experimental variable when investigators assess biological performance or disease-related outcomes.
Local blood supply, tissue architecture, and anatomical connections are not interchangeable features. Together, they create the immediate environment in which a graft or device must integrate. Evaluating these elements helps explain why an orthotopic model may reveal interactions that are less apparent when the same structure is positioned away from the native site.
Orthotopic transplantation can reproduce more than the presence of a graft. By returning the transplanted structure to the anatomical setting associated with the native organ, investigators can evaluate clinically relevant anatomy and physiology. This context also supports assessment of how disease progresses and how a treatment affects outcomes under conditions that better reflect the intended clinical setting.
In disease models, the main value of orthotopic positioning is anatomical relevance. A transplanted structure or disease model located at the corresponding native site can be studied within the relationships that characterize that site. This may support more informative observations of disease progression and treatment response than a model that does not reproduce the relevant anatomical context.
Researchers may choose an orthotopic approach when they need outcomes that reflect native anatomy, physiology, and local interactions. The approach is relevant to surgical training, transplantation research, device evaluation, and treatment assessment. Its usefulness lies in connecting technical placement with clinically meaningful observations, including integration, disease progression, and therapeutic outcomes.