Proximal Muscles

Proximal muscles are skeletal muscles located closer to the trunk, particularly those that control the shoulders, hips, and major joints of the limbs. They generate movement and stabilize the body by contracting in response to motor nerve signals, producing force through muscle fibers and transmitting it across tendons to bones. In medicine, assessing proximal strength helps clinicians identify patterns of weakness associated with neuromuscular disorders, myopathies, nerve injury, and deconditioning. Findings from activities such as rising from a chair or lifting the arms can guide diagnosis, functional evaluation, rehabilitation planning, and monitoring of treatment outcomes.

Proximal Muscles - Related Videos

Research

JoVE Journal - Medicine
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Method to Measure Tone of Axial and Proximal Muscle

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Cited by 5 •

2011

We have developed a device (Twister) to study the regulation of tonic muscle activity during active postural maintenance. Twister measures torsional resistance and muscular responses in standing subjects during twisting of the body axis. The device can be flexibly configured to study various aspects of tonic control across the neck, trunk, and/or hips.

Research

JoVE Journal - Biology

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

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Cited by 53 •

2012

We describe a method to directly measure muscle force, muscle power, contractile kinetics and fatigability of isolated skeletal muscles in an in vitro system using field stimulation. Valuable information on Ca2+ handling properties and contractile machinery of the muscle can be obtained using different stimulating protocols.

Research

JoVE Journal - Biology
Free Sample

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

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Cited by 75 •

2013

Changes in limb muscle contractile and passive mechanical properties are important biomarkers for muscle diseases. This manuscript describes physiological assays to measure these properties in the murine extensor digitorum longus and tibialis anterior muscles.

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

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Cited by 135 •

2011

Survivors of acute respiratory distress syndrome (ARDS) and critical illness frequently develop long-lasting muscle weakness. Manual muscle testing (MMT) is a standardized clinical examination commonly used to measure strength of peripheral skeletal muscle groups. This video demonstrates MMT using the 6-point Medical Research Council scale.

Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule

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Cited by 3 •

2025

We present an optimized protocol for processing whole human kidneys to isolate and culture primary renal proximal tubule epithelial cells and the application of these cells in a three-dimensional, microfluidic, microphysiological platform to recapitulate the renal proximal tubule.

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