Spatial Learning

Spatial learning is the process by which organisms acquire, store, and use information about locations, distances, and relationships within an environment. It depends on forming internal representations, or cognitive maps, through sensory input, experience, and memory systems that include the hippocampus, where place-cell activity can encode an animal’s position. In medicine, spatial learning tasks help researchers assess memory, navigation, and brain function in studies of aging, neurological disease, and injury. Changes in performance can reveal cognitive impairment and support evaluation of treatments, while research on neural navigation mechanisms informs rehabilitation strategies and the development of models for disorders affecting learning and memory.

Spatial Learning - Related Videos

Research

JoVE Journal - Neuroscience

Assessing Spatial Learning and Memory in Small Squamate Reptiles

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Cited by 3 •

2017

This paper describes a modification of the Barnes maze, a standard rodent paradigm used to assess spatial memory and learning, for use in small squamate reptiles.

Research

JoVE Journal - Neuroscience
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Using MazeSuite and Functional Near Infrared Spectroscopy to Study Learning in Spatial Navigation

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Cited by 209 •

2011

MazeSuite is a complete toolset to prepare, present and analyze navigational and spatial experiments. Functional near-infrared spectroscopy (fNIR) is an optical brain imaging technique that enables noninvasive and portable monitoring of cerebral blood oxygenation changes. This paper summarizes collective use of MazeSuite and fNIR within a cognitive processing learning paradigm.

Research

JoVE Journal - Behavior
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The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice

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Cited by 3 •

2024

Here, we present a protocol for the active place avoidance test, a hippocampus-dependent spatial learning paradigm designed for rodents. Altering key parameters allows for re-testing of animals before and after treatments or over time.

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

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Cited by 2 •

2015

We describe an immunohistochemistry protocol to study the profile of hippocampal neuron activation following exposure to a spatial learning task in a mouse model characterized by cognitive deficits of neurodevelopmental origin. This protocol can be applied to both genetic or pharmacological mouse models characterized by cognitive deficits.

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

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Cited by 8 •

2016

To investigate the co-morbid Alzheimer's disease (AD) and stroke condition in a novel model, three behavior tasks are described that assess both motor control and cognitive behaviors. These tasks include the beam-walk task, cylinder task and Morris water maze.

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