Here, we present a protocol for the active place avoidance test, a hippocampus-dependent spatial learning paradigm designed for rodents. Altering key parameters allows for re-testing of animals before and after treatments or over time.
Ali, A. A., Walker, T. L., Blackmore, D. G. The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice. J. Vis. Exp. (204), e65935, doi:10.3791/65935 (2024).