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Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer’s Disease with Stroke
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JoVE Journal Medicine
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer’s Disease with Stroke

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer’s Disease with Stroke

DOI:
10.3791/53089-v

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09:45 min

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March 22, 2016

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, , , ,
1Anatomy and Cell Biology, Schulich School of Medicine and Dentistry,Western University

Chapters

  • 00:05Title
  • 01:03Cylinder Task for Gross Forelimb Motor Assessment
  • 02:37Beam-walk Task for Gross Motor Assessment
  • 04:27Morris Water Maze for Spatial Learning and Reference Memory
  • 07:33Results: A Comorbid Rat Model of Alzheimer’s Disease and Stroke Demonstrates Locomotion and Reference Memory Deficits
  • 09:11Conclusion

Summary

Automatic Translation

Automatic Translation

To investigate the co-morbid Alzheimer's disease (AD) and stroke condition in a novel model, three behavior tasks are described that assess both motor control and cognitive behaviors. These tasks include the beam-walk task, cylinder task and Morris water maze.

Tags

Keywords: Motor FunctionSpatial LearningReference MemoryAlzheimer’s DiseaseStrokeComorbid ModelBehavioral AssessmentMotor DeficitCognitive DeclineDementiaPreventative CompoundsCylinder ApparatusVideo TrackingFour-limb Contacts

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