Systolic Dysfunction
Systolic Dysfunction - Related Videos
07:13
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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Cited by 1 •
2020
We describe the creation of a rat model of pressure overload induced moderate remodeling and early systolic dysfunction where signal transduction pathways involved in the initiation of the remodeling process are activated. This animal model will aid in identifying molecular targets for applying early therapeutic anti-remodeling strategies for heart failure.
06:38
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Cited by 14 •
2016
Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.
06:26
Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Cited by 1 •
2025
Mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD) with metabolic dysfunction, hepatic gene expression changes, and liver histopathological alterations that resemble human MASLD, including fibrosis that progresses to advanced fibrosis stage 3. This model can be used in studies of MASLD pathophysiology and in pre-clinical studies of new therapies.
09:39
Mapping Dysfunctional Protein-Protein Interactions in Disease
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2025
Here, we present a protocol to enable the capture and identification of disease-specific protein-protein interactions from native cells and tissues using chemical probes and mass spectrometry. The resulting interaction datasets are analyzed through a dedicated web-based platform to reveal dynamic network dysfunctions and pathway alterations linked to disease.
10:20
Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
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Cited by 17 •
2013
A specific and rapid protocol to simultaneously investigate right heart function, lung inflammation, and the immune response is described as a learning tool. Video and figures describe physiology and microdissection techniques in an organized team-approach that is adaptable to be used for small to large sized studies.
FAQs
When ventricular contraction falls, the body can respond by increasing heart rate, retaining fluid, and raising vascular resistance. These changes may temporarily support circulation despite reduced pumping performance, but they also alter the workload and fluid state faced by the heart. In clinical assessment, recognizing these responses helps connect reduced contractile function with symptoms and disease progression.
They provide complementary measures of impaired pump performance. Stroke volume indicates how much blood leaves the ventricle with each beat, while ejection fraction expresses the proportion ejected. Tracking both helps characterize reduced systolic function and supports recognition of heart failure with reduced ejection fraction, an important clinical category for assessment and treatment planning.
Myocardial infarction and cardiomyopathy represent different clinical contexts for investigating the same impaired pumping pattern. When clinicians evaluate systolic dysfunction, considering these causes helps link the functional finding to an underlying cardiac disorder. That connection can influence interpretation of testing and selection of management goals directed at the responsible disease process.
Echocardiography is a central way to assess systolic function because it helps evaluate ventricular performance in a clinical setting. Its findings can contribute to identifying heart failure with reduced ejection fraction and to investigating whether reduced function fits a suspected condition such as myocardial infarction or cardiomyopathy. The results therefore support both classification and cause-focused evaluation.
Related tests are useful when clinicians need more than a single functional measurement. Used alongside echocardiography, they can support evaluation of systolic function, help investigate possible causes, and contribute to identifying heart failure with reduced ejection fraction. Their role is complementary: they extend clinical assessment rather than replace interpretation of ventricular performance.
Treatment planning focuses not only on relieving symptoms but also on limiting ventricular remodeling and improving clinical outcomes. This makes the underlying mechanism clinically important: therapies are selected with the goals of addressing the consequences of reduced contractile performance and reducing harmful progression. In medicine, these goals connect test results with long-term management.