Electrical Pain Threshold

Electrical pain threshold is the minimum intensity of an electrical stimulus that a person identifies as painful, providing a controlled measure of pain sensitivity in medicine and biomedical research. During testing, electrodes deliver brief, gradually increasing current pulses to the skin, while the participant signals when the sensation first becomes painful; the response reflects activation of pain-sensing nerve pathways and is influenced by stimulus parameters and individual perception. Researchers use this measure to compare pain sensitivity, evaluate analgesic effects, and investigate changes in sensory function associated with injury, disease, or treatment. Standardized testing can support reproducible studies of human pain mechanisms.

Electrical Pain Threshold - Related Videos

Research

JoVE Journal - Behavior
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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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Cited by 17 •

2016

Human pain models are valuable tools used to assess the analgesic potential of novel compounds and predict their clinical efficacy, especially when used in an integrated manner. Although implementation of these models is complex, with proper execution, the pain models described in this protocol can provide predictive and reliable results.

Research

JoVE Journal - Neuroscience
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Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

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Cited by 5 •

2023

APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and Aδ-fiber nociceptors.

Research

JoVE Journal - Behavior

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

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Cited by 8 •

2017

Psychophysical methods such as the QUEST estimation procedure can efficiently yield robust estimates of the stimulation intensity at which nonpainful sensations transition into painful sensations. By stimulating repeatedly at the threshold intensity, the variability in rating responses can directly be attributed to perceptual classifications in subsequent analyses.

Research

JoVE Journal - Biology
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Determining heat and mechanical pain threshold in inflamed skin of human subjects

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Cited by 21 •

2009

Algorithms assessing heat and mechanical pain thresholds in experimentally inflamed skin of human study subjects are shown. The two pain testing paradigms independently examine nociceptive processing by the two major peripheral nerve fiber populations transmitting pain, i.e., non-myelinated C fibers and small myelinated A-delta fibers.

Research

JoVE Journal - Medicine
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Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity

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Cited by 9 •

2013

The purpose is to present a new method, breathing-control electrical stimulation (BreEStim) for management of neuropathic pain and spasticity.

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