Thrombus Canalization
Thrombus Canalization - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
06:26
Capturing Flow-weighted Water and Suspended Particulates from Agricultural Canals During Drainage Events
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Cited by 2 •
2017
Nutrients present in particulate form can contribute significantly to the overall loads in agricultural drainage waters. This study describes a novel method to capture flow-weighted water and suspended particulates from farm canal drainage over the entire duration of the drainage event.
FAQs
During maturation, inflammatory cells, fibroblasts, and endothelial cells invade the thrombus and reorganize its matrix. This coordinated remodeling changes the clot’s structure and creates tissue that can support passage formation. Endothelial-lined channels may emerge and connect with the vessel lumen, establishing a basis for partial restoration of flow without implying that the original vessel has returned to normal.
Canalization can improve patency while leaving the vessel narrowed or associated with abnormal flow. The newly formed passages do not necessarily recreate the original lumen or normal vascular architecture. Consequently, channels through an older thrombus should not be interpreted as complete resolution or full recovery of vascular function, particularly when persistent obstruction remains.
Canalization describes channel formation within an organized clot, whereas resolution refers more broadly to the evolution or reduction of thrombotic obstruction. These processes may overlap, but a recanalized vessel can still contain narrowing or abnormal flow. Evidence of channels therefore indicates remodeling and partial patency, not necessarily disappearance of the thrombus or restoration of normal vessel structure.
Interpretation focuses on whether channels within an organized thrombus appear to connect with the vessel lumen and whether narrowing or abnormal flow remains. The imaging finding should therefore be read as evidence of remodeling and partial restoration of passage, not automatically as complete resolution. This approach helps distinguish persistent obstruction from a vessel that has regained some, but not necessarily normal, patency.
The process is especially relevant in chronic venous and arterial thromboses, where the clot has had time to evolve and remodel. Recognizing canalization helps explain why blood may pass through a previously obstructed segment while residual narrowing or abnormal flow persists. It provides context for understanding the continuing vascular consequences of an established thrombus.
In evaluating treatment outcomes, canalization helps place vascular imaging findings in context. Evidence of channels may indicate partial restoration of flow, whereas persistent narrowing or abnormal flow suggests that obstruction has not been fully corrected. These findings help distinguish partial remodeling from complete resolution, without treating recanalization alone as proof of normal vascular function.