C57bl/6 Mice
C57bl/6 Mice - Related Videos
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Cited by 38 •
2015
The transfer of bm12 lymphocytes into a C57BL/6 recipient is an established model of systemic lupus erythematosus. Here we describe how to initiate disease using this model and how to characterize T follicular helper cells, germinal center B cells and plasma cells by flow cytometry.
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Cited by 6 •
2021
Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.
08:20
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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2018
Murine distal colostomy provides a murine model for human diversion colitis, a predominantly lymphocytic colitis in colon segment excluded from the fecal stream.
07:15
Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
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Cited by 3 •
2024
We developed an accelerated social defeat stress model for adolescent C57BL/6 mice, which works in both males and females and allows exposure during discrete adolescent periods. Exposure to this model induces social avoidance, but only in a subset of defeated male and female mice.
08:52
Fabrication and Characterization of 3BDO-Loaded Dissolvable Microneedle Patches for Hair Regrowth in C57BL/6 Mice
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2026
This protocol describes the fabrication, characterization, and application of 3BDO-loaded dissolvable microneedle patches for transdermal drug delivery in a mouse hair-regrowth model.
FAQs
Near genetic uniformity reduces background variation between animals, making differences in brain function, behavior, or disease-related phenotypes easier to associate with the experimental manipulation. Because researchers can introduce targeted mutations or transgenes onto a common background, comparisons across groups become more reproducible. This supports controlled testing of how specific genetic changes influence neural outcomes.
A mutation or transgene can produce different neural phenotypes depending on the background in which it is studied. Using C57BL/6 mice provides a well-characterized, relatively consistent background for examining those effects. The background therefore helps researchers distinguish consequences associated with the introduced genetic change from variation already present among experimental animals.
Sensory, motor, and stress responses can vary in ways that influence behavioral measurements independently of the neural process under investigation. For example, a performance difference may reflect altered movement or stress sensitivity rather than the intended cognitive or neurological phenotype. Accounting for these characteristics helps researchers interpret behavioral data more cautiously and accurately.
Standardized results in one inbred strain do not necessarily represent all biological contexts. Sex, genetic strain, and other model systems can influence neural phenotypes, behavior, and disease-related responses. Validation across these dimensions helps determine whether an observation reflects a broadly relevant mechanism or a feature specific to the C57BL/6 background or experimental setting.
Investigators can use this strain when they need reproducible behavioral phenotypes and a consistent genetic background for comparing experimental groups. Study design should also account for strain-associated sensory, motor, and stress responses, since these factors may affect test performance. Appropriate interpretation then separates the measured behavioral outcome from influences unrelated to the primary neural question.
C57BL/6 mice support studies of brain function and behavior, neurodevelopment, neuroimmunology, and neurodegeneration. Their standardized genetic background allows investigators to introduce targeted mutations or transgenes and then evaluate resulting neural phenotypes. This makes the strain useful across research programs that require controlled comparisons, while still leaving cross-strain and cross-model validation important.
A well-characterized genome gives researchers a defined reference for linking genetic manipulations with neural phenotypes. When animals share a near-uniform background, observed differences can be compared more consistently across experiments and groups. In neuroscience, this supports clearer analysis of changes in brain function, behavior, development, immune interactions, or neurodegeneration associated with the study design.