A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:04Introduction
- 01:07Laparotomy and Exposing the Pancreas
- 02:17Severe Acute Pancreatitis Induction
- 03:30Methods for Analysis
- 05:13Results: Analysis of Histological and Serological Changes after Induction of Acute Pancreatitis
- 06:00Conclusion
Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.
