Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging - Related Videos
09:15
fMRI: Functional Magnetic Resonance Imaging
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2023
Functional magnetic resonance imaging (fMRI) is a non-invasive neuroimaging technique used to investigate human brain function and cognition in both healthy individuals and populations with abnormal brain states. Functional MRI utilizes a magnetic resonance signal to detect changes in blood flow that are coupled to neuronal activation when a specific task is performed. This is possible because hemoglobin within the blood has different magnetic properties depending on whether or not it is bound...
13:05
Functional Magnetic Resonance Imaging (fMRI) with Auditory Stimulation in Songbirds
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Cited by 12 •
2013
This article shows an optimized procedure for imaging of the neural substrates of auditory stimulation in the songbird brain using functional Magnetic Resonance Imaging (fMRI). It describes the preparation of the sound stimuli, the positioning of the subject and the acquisition and subsequent analysis of the fMRI data.
11:37
Cardiac Magnetic Resonance Imaging
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2023
Source: Frederick W. Damen and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana In this video, high field, small-bore magnetic resonance imaging (MRI) with physiological monitoring is demonstrated to acquire gated cine loops of the murine cardiovascular system. This procedure provides a basis for assessing left-ventricular function, visualizing vascular networks, and quantifying motion of organs due to respiration. Comparable small animal...
09:08
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Cited by 59 •
2011
Magnetic resonance imaging (MRI) has become an increasingly popular tool for examining the phenotype of genetically altered mice. This article illustrates the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI.
10:06
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
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Cited by 8 •
2012
This article describes techniques to perform high-resolution functional magnetic resonance imaging with 1.2 mm sampling in human midbrain and subcortical structures using a 3T scanner. Use of these techniques to resolve topographic maps of visual stimulation in the human superior colliculus (SC) is given as an example.
FAQs
Functional magnetic resonance imaging links local neural activity to vascular and metabolic responses rather than recording neural signals directly. When activity changes, blood flow and oxygen use alter the balance of oxygenated and deoxygenated hemoglobin, which changes the magnetic resonance signal. This coupling lets investigators estimate where activity-related physiological changes occur while interpreting the result as an indirect marker of brain function.
The relative amounts of oxygenated and deoxygenated hemoglobin influence the magnetic resonance signal detected by fMRI. Neural activity changes blood flow and metabolism, which can shift that balance locally and produce measurable BOLD differences. These signal changes provide the physiological basis for comparing activity across brain areas or across periods associated with different cognitive or behavioral states.
Functional magnetic resonance imaging can identify both localized activity and coordinated patterns involving multiple brain regions. A regional view helps associate particular areas with functions such as movement or language, whereas a network view helps describe how distributed regions support cognition and behavior together. This broader perspective is useful when brain functions depend on interactions rather than on one isolated site.
Following signal changes over time helps researchers relate brain activity to evolving perceptual, cognitive, or behavioral processes. Instead of considering only whether a region is involved, investigators can examine when activity changes occur in relation to tasks or behaviors. This temporal information supports studies of functions such as memory, decision-making, language, and movement.
Researchers apply functional magnetic resonance imaging to questions about perception, memory, language, movement, and decision-making. By identifying activity-related changes in relevant regions and networks, they can examine how the brain supports these functions. The same approach also allows investigators to relate measured brain activity to behavior, extending interpretation beyond anatomy alone.
In neurological and psychiatric research, fMRI helps investigators examine how brain activity and connected networks relate to disorders. It can also be used to assess treatment-related changes by comparing activity patterns across relevant conditions or time points. Because the method does not expose participants to ionizing radiation, it supports repeated examination of brain function in these research contexts.