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10:04
Flame Experiments at the Advanced Light Source: New Insights into Soot Formation Processes
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Cited by 4 •
2014
Gas sampling from laboratory-scale flames with online analysis of all species by mass spectrometry is a powerful method to investigate the complex mixture of chemical compounds occurring during combustion processes. Coupled with tunable soft ionization via synchrotron-generated vacuum-ultraviolet radiation, this technique provides isomer-resolved information and potentially fragment-free mass spectra.
10:32
Sample Preparation and Transfer Protocol for In-Vacuum Long-Wavelength Crystallography on Beamline I23 at Diamond Light Source
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Cited by 2 •
2021
Here, we present a protocol for cryogenic sample preparation and transfer of crystals into the vacuum endstation on beamline I23 at Diamond Light Source, for long-wavelength macromolecular X-ray crystallography experiments.
06:19
Fixed Target Serial Data Collection at Diamond Light Source
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Cited by 22 •
2021
We present a comprehensive guide to fixed target sample preparation, data collection, and data processing for serial synchrotron crystallography at Diamond beamline I24.
08:56
Investigation of a Blue Light LED Device to Suppress Wound Pathogens Using a Collagen-Based Synthetic Skin Model
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2026
A 405 nm blue light LED device demonstrates antimicrobial efficacy against a broad range of wound pathogens when evaluated on a collagen-based synthetic skin model. This simplified in vitro approach offers a reproducible and ethically viable alternative for early-phase evaluation of light-based antimicrobial therapies.
08:35
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Cited by 78 •
2021
This paper describes the complete XChem process for crystal-based fragment screening, starting from applying for access and all subsequent steps to data dissemination.
FAQs
The emitted wavelength depends primarily on the semiconductor composition, whereas the electrical drive controls how much light the device produces. This separation lets an experimenter select a spectral range and then adjust intensity for the preparation. In neuroscience, those variables help align illumination or stimulation with the experimental design.
Rapid switching matters because neural experiments often depend on precise timing. An LED can be turned on and off quickly, allowing light delivery to be coordinated with an experimental stimulus or behavioral event. Its low heat output also helps reduce thermal disturbance, making the source useful when temperature could affect the neural preparation.
The appropriate spectral range and intensity depend on the intended application rather than on a single universal setting. Semiconductor composition determines whether the source emits in the visible or near-infrared range, while drive conditions influence intensity. Researchers can therefore select output characteristics according to whether they need illumination, light-based stimulation, or optogenetic activation.
A basic setup begins by choosing the LED's emitted spectral range and configuring its electrical drive to control intensity. The source can then illuminate a sample directly or connect with fiber optics for targeted delivery. Timing the drive provides controlled light delivery, while the low-heat design supports use near neural preparations.
Researchers can apply an LED light source in neuroscience in three broad ways: illuminating a sample, stimulating a light-sensitive neural system, or activating a genetically encoded optogenetic tool. The choice determines whether light serves primarily as observation, a sensory or neural stimulus, or an actuator for manipulating neural activity.
Fiber-optic compatibility extends the usefulness of the source when light must reach a particular location in a preparation. This arrangement can support experiments on neural circuits, sensory processing, and behavior by delivering light where and when the study requires it. The resulting control helps relate optical stimulation or illumination to neural and behavioral responses.