Modular Networks

Modular networks are systems organized into groups of densely interconnected nodes, or modules, with fewer connections between groups. In neuroscience, this architecture enables specialized processing within modules while coordinating information across them through intermodule links, balancing functional segregation with global integration. Network scientists identify modules in brain connectivity data using graph-theoretic methods and compare their organization across regions, developmental stages, tasks, or clinical conditions. Studying modular networks helps explain how the brain supports complex cognition, adapts to changing demands, and maintains efficient communication, while also revealing how altered connectivity may contribute to neurological and psychiatric disorders.

Modular Networks - Related Videos

Research

JoVE Journal - Neuroscience

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

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Cited by 6 •

2015

This manuscript describes a protocol to grow in vitro modular networks consisting of spatially confined, functionally inter-connected neuronal circuits. A polymeric mask is used to pattern a protein layer to promote cellular adhesion over the culturing substrate. Plated neurons grow on coated areas establishing spontaneous connections and exhibiting electrophysiological activity.

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

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2025

This article presents a step-by-step protocol demonstrating how Modular Cloning (MoClo) can be adapted for the cloning of polycistronic operons.

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

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Cited by 4 •

2016

We describe the fabrication of micropatterned hydrogel sheets using a simple process, which can be assembled and manipulated in a freestanding form. Using these modular hydrogel sheets, a simple macro-scaled 3D cell culture system can be generated with a controlled cellular microenvironment.

Education

JoVE Core - Molecular Biology

Protein Networks

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2020

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions. These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Research

JoVE Journal - Biology
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A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms

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2025

This protocol delivers a modular, BSL-2 workflow combining crystal-violet biomass assays, time-lapse phase-contrast kinetics, confocal 3-D/matrix mapping, SEM ultrastructure, and an in vivo hamster infection module to cultivate, quantify, characterize and investigate Leptospira biofilm functional role, enabling standardized evaluation of mutants and anti-biofilm interventions across laboratories.

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