Olfactory Response
Olfactory Response - Related Videos
08:08
Odorant-induced Responses Recorded from Olfactory Receptor Neurons using the Suction Pipette Technique
0 Views •
Cited by 13 •
2012
Olfactory receptor neurons (ORNs) convert odor signals first into a receptor current that in turn triggers action potentials that are conveyed to second order neurons in the olfactory bulb. Here we describe the suction pipette technique to record simultaneously the odorant-induced receptor current and action potentials from mouse ORNs.
06:55
Using Single Sensillum Recording to Detect Olfactory Neuron Responses of Bed Bugs to Semiochemicals
0 Views •
Cited by 3 •
2016
Bed bugs rely on olfactory receptor neurons housed in their antennal olfactory sensilla to detect semiochemicals in the environment. Utilizing single sensillum recording, we demonstrate a method to evaluate bed bug response to semiochemicals and explore the coding process involved.
09:51
Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording
0 Views •
Cited by 34 •
2010
The electroolfactogram (EOG) recording is an informative, easy-to-conduct, and reliable way of assessing olfactory function at the level of the olfactory epithelium. This protocol describes a recording setup, mouse tissue preparation, data collection, and basic data analysis.
02:23
Navigational Behavior of Drosophila Larvae in Response to Optogenetic Stimulation of Olfactory Sensory Neurons
0 Views •
2025
This video demonstrates a study of the navigational behavior of Drosophila larvae in response to optogenetic stimulation of olfactory sensory neurons (ORNs). Transgenic Drosophila larvae expressing light-sensitive ion channels in the ORNs are placed on agarose within a behavior arena. Optogenetic stimulation with light opens the channels, causing a cation influx that triggers the transmission of the signal to the brain, and the navigation behavior is recorded.
04:28
Drosophila Y-maze Assay: A Method to Assess Olfactory Responses in Flies
0 Views •
2023
This video describes a method to test olfactory exploratory behavior in the fruit fly, called the Y-maze. The featured protocol clip demonstrates how to set up and conduct the assay.
FAQs
Binding activates a G protein–coupled signaling pathway inside the olfactory sensory neuron. This pathway raises cyclic AMP levels, which opens ion channels and changes the cell’s electrical state. The resulting signal is carried from the nasal epithelium to the olfactory bulb, creating the neural input that later brain regions can interpret.
They convert a chemical recognition event into an electrical signal. Receptor activation increases cyclic AMP, and the resulting opening of ion channels changes the membrane activity of the sensory neuron. This conversion allows odorant information to leave the nasal epithelium as neural signals rather than remaining a local molecular interaction.
Different odorant molecules activate specific receptors, producing patterns of neural activity that can be processed as odor information. Signals first reach the olfactory bulb and then higher brain regions, where they contribute to sensory coding and links with memory, emotion, and behavior. This makes the pathway useful for studying how neural circuits represent environmental signals.
Detection measurements assess whether an organism or participant responds to the presence of an odor, whereas discrimination measurements examine whether different odors can be distinguished. Comparing changes in these abilities helps separate broad changes in olfactory function from changes in how odor information is differentiated, providing a more focused view of sensory processing.
Altered odor detection or discrimination can provide evidence about how sensory processing is functioning within the nervous system. Because olfactory signals engage the olfactory bulb and higher brain regions, these measures can also inform studies of neural circuits, cognition-related processes, and neurological disorders. The results connect observable sensory performance with underlying brain function.
Olfactory signals provide a route for examining how sensory information becomes linked with higher-order brain activity. After processing in the olfactory bulb, information reaches higher brain regions associated with sensory coding, memory, emotion, and behavior. Researchers can therefore use odor-related responses to investigate connections between neural representation and broader behavioral or cognitive outcomes.