Spect Imaging
Spect Imaging - Related Videos
09:08
Combined SPECT and CT Imaging to Visualize Cardiac Functionality
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2023
Source: Alycia G. Berman, James A. Schaber, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Here we will demonstrate the fundamentals of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging using mice. The technique involves injecting a radionuclide into a mouse, imaging the animal after it is distributed throughout the body, and then reconstructing the produced images to create a volumetric dataset. This can...
09:49
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Cited by 10 •
2020
This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure overlapping.
10:53
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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Cited by 37 •
2012
A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.
13:45
Hybrid µCT-FMT imaging and image analysis
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Cited by 34 •
2015
We describe a protocol for hybrid imaging, combining fluorescence-mediated tomography (FMT) with micro computed tomography (µCT). After fusion and reconstruction, we perform interactive organ segmentation to extract quantitative measurements of the fluorescence distribution.
09:08
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Cited by 59 •
2011
Magnetic resonance imaging (MRI) has become an increasingly popular tool for examining the phenotype of genetically altered mice. This article illustrates the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI.
FAQs
The rotating gamma camera records gamma-ray photons emitted by the radiotracer from multiple viewing angles. Each angle contributes a different projection of tracer distribution, allowing computer reconstruction to localize activity within the brain. This process converts photon measurements into cross-sectional and three-dimensional views that reveal regional patterns rather than a single two-dimensional image.
Tracer uptake provides a spatial indicator of physiological activity in different brain regions. In neuroscience, these patterns can be examined in relation to cerebral blood flow, neurotransmitter systems, or regional brain function. The resulting distribution helps researchers and clinicians identify functional differences between areas of the brain without relying only on anatomical appearance.
SPECT imaging adds functional information to the anatomical information provided by MRI or CT. MRI and CT help depict brain structure, whereas SPECT can show physiological activity through tracer distribution and can measure function over time. Using these approaches together can provide a broader view of how brain anatomy relates to regional function.
The workflow begins when a radiotracer is present and emits gamma rays. A gamma camera rotates around the subject, detecting the photons from multiple angles. A computer then reconstructs those measurements into cross-sectional and three-dimensional images of tracer uptake. The reconstructed patterns can subsequently be examined for regional brain function or cerebral blood flow.
SPECT can support investigations of cerebral blood flow, neurotransmitter systems, and regional brain function. These measurements make the technique relevant to studies and evaluations involving stroke, epilepsy, dementia, and movement disorders. Its contribution is especially useful when the research question concerns physiological activity or functional patterns rather than brain anatomy alone.
In neuroscience research and clinical evaluation, SPECT findings can help characterize functional patterns associated with stroke, epilepsy, dementia, and movement disorders. Researchers can examine how tracer uptake varies across brain regions and relate those patterns to cerebral blood flow, neurotransmitter systems, or regional function. The method therefore complements structural assessment with physiological information.